@article{fdi:010058996,
  title = {{F}irst attempt to validate human {I}gg antibody response to nterm-34kda salivary peptide as biomarker for evaluating exposure to {A}edes aegypti bites},
  author = {{N}dille, {E}.{E}. and {D}oucour{\'e}, {S}. and {D}amien, {G}. and {M}ouchet, {F}ran{\c{c}}ois and {D}ram{\'e}, {P}apa {M}aktar and {C}orn{\'e}lie, {S}ylvie and {N}oukpo, {H}. and {Y}amadjako, {S}. and {D}jenontin, {A}. and {M}oiroux, {N}icolas and {M}iss{\'e}, {D}oroth{\'e}e and {A}kogbeto, {M}. and {C}orbel, {V}incent and {H}enry, {M}.{C}. and {C}handre, {F}abrice and {B}aldet, {T}. and {R}emou{\'e}, {F}ranck},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {M}uch effort is being devoted for developing new indicators to evaluate the human exposure to {A}edes mosquito bites and the risk of arbovirus transmission. {H}uman antibody ({A}b) responses to mosquito salivary components could represent a promising tool for evaluating the human-vector contact. {M}ethodology/{P}rincipal findings: {T}o develop a specific biomarker of human exposure to {A}edes aegypti bites, we measured {I}g{G} {A}b response to {A}e. aegypti {N}term-34 k{D}a salivary peptide in exposed children in 7 villages of {S}outhern {B}enin ({W}est {A}frica). {R}esults showed that specific {I}g{G} response presented high inter-individual heterogeneity between villages. {I}g{G} response was associated with rainfall and {I}g{G} level increased from dry (low exposure) to rainy (high exposure) seasons. {T}hese findings indicate that {I}g{G} {A}b to {N}term-34 k{D}a salivary peptide may represent a reliable biomarker to detect variation in human exposure to {A}e. aegypti bites. {C}onclusion/{S}ignificance: {T}his preliminary study highlights the potential use of {A}b response to this salivary peptide for evaluating human exposure to {A}e. aegypti. {T}his biomarker could represent a new promising tool for assessing the risk of arbovirus transmission and for evaluating the efficacy of vector control interventions.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {6},
  numero = {11},
  pages = {e1905},
  ISSN = {1935-2735},
  year = {2012},
  DOI = {10.1371/journal.pntd.0001905},
  URL = {https://www.documentation.ird.fr/hor/fdi:010058996},
}