@article{fdi:010058986,
  title = {{I}nsights into {D}ynamics of {M}obile {G}enetic {E}lements in {H}yperthermophilic {E}nvironments from {F}ive {N}ew {T}hermococcus {P}lasmids},
  author = {{K}rupovic, {M}. and {G}onnet, {M}. and {B}en {H}ania, {W}ajdi and {F}orterre, {P}. and {E}rauso, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}obilome of hyperthermophilic archaea dwelling in deep-sea hydrothermal vents is poorly characterized. {T}o gain insight into genetic diversity and dynamics of mobile genetic elements in these environments we have sequenced five new plasmids from different {T}hermococcus strains that have been isolated from geographically remote hydrothermal vents. {T}he plasmids were ascribed to two subfamilies, p{TN}2-like and p{EXT}9a-like. {G}ene content and phylogenetic analyses illuminated a robust connection between p{TN}2-like plasmids and {P}yrococcus abyssi virus 1 ({PAV}1), with roughly half of the viral genome being composed of genes that have homologues in plasmids. {U}nexpectedly, p{EXT}9a-like plasmids were found to be closely related to the previously sequenced plasmid p{METVU}01 from {M}ethanocaldococcus vulcanius {M}7. {O}ur data suggests that the latter observation is most compatible with an unprecedented horizontal transfer of a p{EXT}9a-like plasmid from {T}hermococcales to {M}ethanococcales. {G}ene content analysis revealed that thermococcal plasmids encode {H}fq-like proteins and toxin-antitoxin ({TA}) systems of two different families, {V}ap{BC} and {R}el{BE}. {N}otably, although abundant in archaeal genomes, to our knowledge, {TA} and hfq-like genes have not been previously found in archaeal plasmids or viruses. {F}inally, the plasmids described here might prove to be useful in developing new genetic tools for hyperthermophiles.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {8},
  numero = {1},
  pages = {e49044},
  ISSN = {1932-6203},
  year = {2013},
  DOI = {10.1371/journal.pone.0049044},
  URL = {https://www.documentation.ird.fr/hor/fdi:010058986},
}