@article{fdi:010058974,
  title = {{P}oint-of-care laboratory of pathogen diagnosis in rural {S}enegal},
  author = {{S}okhna, {C}heikh and {M}ediannikov, {O}leg and {F}enollar, {F}. and {B}assene, {H}. and {D}iatta, {G}. and {T}all, {A}. and {T}rape, {J}ean-{F}ran{\c{c}}ois and {D}rancourt, {M}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}n tropical {A}frica, where the spectrum of the bacterial pathogens that cause fevers is poorly understood and molecular-based diagnostic laboratories are rare, the time lag between test results and patient care is a critical point for treatment of disease. {M}ethodology/{P}rincipal {F}indings: {W}e implemented {POC} laboratory in rural {S}enegal to resolve the time lag between test results and patient care. {D}uring the first year of the study ({F}ebruary 2011 to {J}anuary 2012), 440 blood specimens from febrile patients were collected in {D}ielmo and {N}diop villages. {A}ll samples were screened for malaria, dengue fever, {B}orrelia spp., {C}oxiella burnetii, {T}ropheryma whipplei, {R}ickettsia conorii, {R}. africae, {R}. felis, and {B}artonella spp. {C}onclusions/{S}ignificance: {W}e identified {DNA} from at least one pathogenic bacterium in 80/440 (18.2%) of the samples from febrile patients. {B}. crocidurae was identified in 35 cases (9.5%), and {R}. felis {DNA} was found in 30 cases (6.8%). {T}he {DNA} of {B}artonella spp. was identified in 23/440 cases (4.3%), and {DNA} of {C}. burnetii was identified in 2 cases (0.5%). {T}. whipplei (0.2%) was diagnosed in one patient. {N}o {DNA} of {R}. africae or {R}. conorii was identified. {A}mong the 7 patients co-infected by two different bacteria, we found {R}. felis and {B}. crocidurae in 4 cases, {B}. crocidurae and {B}artonella spp. in 2 cases, and {B}. crocidurae and {C}. burnetii in 1 case. {M}alaria was diagnosed in 54 cases. {I}n total, at least one pathogen (bacterium or protozoa) was identified in 127/440 (28.9%) of studied samples. {H}ere, the authors report the proof of concept of {POC} in rural tropical {A}frica. {D}iscovering that 18.2% of acute infections can be successfully treated with doxycycline should change the treatment strategy for acute fevers in {W}est {A}frica.},
  keywords = {{SENEGAL}},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {7},
  numero = {1},
  pages = {e1999},
  ISSN = {1935-2735},
  year = {2013},
  DOI = {10.1371/journal.pntd.0001999},
  URL = {https://www.documentation.ird.fr/hor/fdi:010058974},
}