@article{fdi:010058852,
  title = {{E}pidemiology of sleeping sickness in {B}offa ({G}uinea) : where are the trypanosomes ?},
  author = {{K}agbadouno, {M}. {S}. and {C}amara, {M}. and {R}ouamba, {J}. and {R}ayaisse, {J}. {B}. and {T}raor{\'e}, {I}. {S}. and {C}amara, {O}. and {O}nikoyamou, {M}. {F}. and {C}ourtin, {F}abrice and {R}avel, {S}ophie and {D}e {M}eeûs, {T}hierry and {B}ucheton, {B}runo and {J}amonneau, {V}incent and {S}olano, {P}hilippe},
  editor = {},
  language = {{ENG}},
  abstract = {{H}uman {A}frican {T}rypanosomiasis ({HAT}) in {W}est {A}frica is a lethal, neglected disease caused by {T}rypanosoma brucei gambiense transmitted by the tsetse {G}lossina palpalis gambiensis. {A}lthough the littoral part of {G}uinea with its typical mangrove habitat is the most prevalent area in {W}est {A}frica, very few data are available on the epidemiology of the disease in such biotopes. {A}s part of a {HAT} elimination project in {G}uinea, we carried a cross-sectional study of the distribution and abundance of people, livestock, tsetse and trypanosomes in the focus of {B}offa. {A}n exhaustive census of the human population was done, together with spatial mapping of the area. {E}ntomological data were collected, a human medical survey was organized together with a survey in domestic animals. {I}n total, 45 {HAT} cases were detected out of 14445 people who attended the survey, these latter representing 50.9% of the total population. {P}otential additional carriers of {T}. b. gambiense were also identified by the trypanolysis test (14 human subjects and two domestic animals). {N}o trypanosome pathogenic to animals were found, neither in the 874 tsetse dissected nor in the 300 domestic animals sampled. {H}igh densities of tsetse were found in places frequented by humans, such as pirogue jetties, narrow mangrove channels and watering points. {T}he prevalence of {T}. b. gambiense in humans, combined to low attendance of the population at risk to medical surveys, and to an additional proportion of human and animal carriers of {T}. b. gambiense who are not treated, highlights the limits of strategies targeting {HAT} patients only. {I}n order to stop {T}. b. gambiense transmission, vector control should be added to the current strategy of case detection and treatment. {S}uch an integrated strategy will combine medical surveillance to find and treat cases, and vector control activities to protect people from the infective bites of tsetse.},
  keywords = {{GUINEE}},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {6},
  numero = {12},
  pages = {e1949},
  ISSN = {1935-2735},
  year = {2012},
  DOI = {10.1371/journal.pntd.0001949},
  URL = {https://www.documentation.ird.fr/hor/fdi:010058852},
}