@article{fdi:010058243,
  title = {{T}ell me a tale of {TALE}s},
  author = {{B}odnar, {A}. {M}. and {B}ernal, {A}. and {S}zurek, {B}oris and {L}opez, {C}. {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}athogenic bacteria of the {X}anthomonas and {R}alstonia genus have developed resourceful strategies creating a favorable environment to multiply and colonize their host plants. {O}ne of these strategies involves the secretion and translocation of several families of effector proteins into the host cell. {T}he transcription activator-like effector ({TALE}) family forms a subset of proteins involved in the direct modulation of host gene expression. {TALE}s include a number of tandem 34-amino acid repeats in their central part, where specific residues variable in two adjacent positions determine {DNA}-binding in the host genome. {T}he specificity of this binding and its predictable nature make {TALE}s a revolutionary tool for gene editing, functional analysis, modification of target gene expression, and directed mutagenesis. {S}everal examples have been reported in higher organisms as diverse as plants, {D}rosophila, zebrafish, mouse, and even human cells. {H}ere, we summarize the functions of {TALE}s in their natural context and the biotechnological perspectives of their use.},
  keywords = {{TAL} effector ; {X}anthomonas ; {P}athogenicity target ; {G}enome editing},
  booktitle = {},
  journal = {{M}olecular {B}iotechnology},
  volume = {53},
  numero = {2},
  pages = {228--235},
  ISSN = {1073-6085},
  year = {2013},
  DOI = {10.1007/s12033-012-9619-3},
  URL = {https://www.documentation.ird.fr/hor/fdi:010058243},
}