Patramool S. auteur aut IRD Choumet V. auteur aut IRD Surasombatpattana P. auteur aut IRD Sabatier L. auteur aut IRD Thomas F. auteur aut IRD Thongrungkiat S. auteur aut IRD Rabilloud T. auteur aut IRD Boulanger N. auteur aut IRD Biron D. G. auteur aut IRD Missé Dorothée auteur aut IRD text journalArticle eng text/pdf born digital access Vector-borne diseases (VBDs) are defined as infectious diseases of humans and animals caused by pathogenic agents such as viruses, protists, bacteria, and helminths transmitted by the bite of blood-feeding arthropod (BFA) vectors. VBDs represent a major public health threat in endemic areas, generally subtropical zones, and many are considered to be neglected diseases. Genome sequencing of some arthropod vectors as well as modern proteomic and genomic technologies are expanding our knowledge of arthropodpathogen interactions. This review describes the proteomic approaches that have been used to investigate diverse biological questions about arthropod vectors, including the interplay between vectors and pathogens. Proteomic studies have identified proteins and biochemical pathways that may be involved in molecular crosstalk in BFA-pathogen associations. Future work can build upon this promising start and functional analyses coupled with interactome bioassays will be carried out to investigate the role of candidate peptides and proteins in BFA-human pathogen associations. Dissection of the hostpathogen interactome will be key to understanding the strategies and biochemical pathways used by BFAs to cope with pathogens. specialized Host-pathogen interaction Microbiology Midgut Saliva Vector-borne diseases 052 020 12 23-24 3510-3523 2012 1615-9853 https://www.documentation.ird.fr/hor/fdi:010058233 10.1002/pmic.201200300 1615-9853 [F B010058233] https://www.documentation.ird.fr/hor/fdi:010058233 https://www.documentation.ird.fr/intranet/publi/2013/01/010058233.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2013-02-06 2017-08-23 fdi:010058233 fre