@article{fdi:010058231,
  title = {{N}ovel simian foamy virus infections from multiple monkey species in women from the {D}emocratic {R}epublic of {C}ongo},
  author = {{S}witzer, {W}. {M}. and {T}ang, {S}. {H}. and {A}huka-{M}undeke, {S}. and {S}hankar, {A}. and {H}anson, {D}. {L}. and {Z}heng, {H}. {Q}. and {A}youba, {A}hidjo and {W}olfe, {N}. {D}. and {L}e{B}reton, {M}. and {D}joko, {C}. {F}. and {T}amoufe, {U}. and {E}steban, {A}mandine and {H}eneine, {W}. and {P}eeters, {M}artine and {W}right, {L}. {L}. and {M}uyembe-{T}amfum, {J}. {J}. and {W}emakoy, {E}. {O}. and {M}ulembakani, {P}. and {H}off, {N}. {A}. and {R}imoin, {A}. {W}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {Z}oonotic transmission of simian retroviruses in {C}entral {A}frica is ongoing and can result in pandemic human infection. {W}hile simian foamy virus ({SFV}) infection was reported in primate hunters in {C}ameroon and {G}abon, little is known about the distribution of {SFV} in {A}frica and whether human-to-human transmission and disease occur. {W}e screened 3,334 plasmas from persons living in rural villages in central {D}emocratic {R}epublic of {C}ongo ({DRC}) using {SFV}-specific {EIA} and {W}estern blot ({WB}) tests. {PCR} amplification of {SFV} polymerase sequences from {DNA} extracted from buffy coats was used to measure proviral loads. {P}hylogenetic analysis was used to define the {NHP} species origin of {SFV}. {P}articipants completed questionnaires to capture {NHP} exposure information. {R}esults: {S}ixteen (0.5%) samples were {WB}-positive; 12 of 16 were from women (75%, 95% confidence limits 47.6%, 92.7%). {S}equence analysis detected {SFV} in three women originating from {A}ngolan colobus or red-tailed monkeys; both monkeys are hunted frequently in {DRC}. {NHP} exposure varied and infected women lived in distant villages suggesting a wide and potentially diverse distribution of {SFV} infections across {DRC}. {P}lasmas from 22 contacts of 8 {WB}-positive participants were all {WB} negative suggesting no secondary viral transmission. {P}roviral loads in the three women ranged from 14 - 1,755 copies/10(5) cells. {C}onclusions: {O}ur study documents {SFV} infection in rural {DRC} for the first time and identifies infections with novel {SFV} variants from {C}olobus and red-tailed monkeys. {U}nlike previous studies, women were not at lower risk for {SFV} infection in our population, providing opportunities for spread of {SFV} both horizontally and vertically. {H}owever, limited testing of close contacts of {WB}-positive persons did not identify human-to-human transmission. {C}ombined with the broad behavioral risk and distribution of {NHP}s across {DRC}, our results suggest that {SFV} infection may have a wider geographic distribution within {DRC}. {T}hese results also reinforce the potential for an increased {SFV} prevalence throughout the forested regions of {A}frica where humans and simians co-exist. {O}ur finding of endemic foci of {SFV} infection in {DRC} will facilitate longitudinal studies to determine the potential for person-to-person transmissibility and pathogenicity of these zoonotic retroviral infections.},
  keywords = {{S}imian foamy virus ; {R}etrovirus ; {Z}oonosis ; {A}frica ; {W}omen ; {T}ransmission ; {P}ublic health ; {E}merging ; {REPUBLIQUE} {DEMOCRATIQUE} {DU} {CONGO}},
  booktitle = {},
  journal = {{R}etrovirology},
  volume = {9},
  numero = {},
  pages = {100},
  ISSN = {1742-4690},
  year = {2012},
  DOI = {10.1186/1742-4690-9-100},
  URL = {https://www.documentation.ird.fr/hor/fdi:010058231},
}