%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Gaayeb, L.
%A Sarr, J. B.
%A Ndiath, Mamadou
%A Hanon, J. B.
%A Debrie, A. S.
%A Seck, M.
%A Schacht, A. M.
%A Remoué, Franck
%A Hermann, E.
%A Riveau, G.
%T Seroprevalence of pertussis in Senegal : a prospective study
%D 2012
%L fdi:010058214
%G ENG
%J Plos One
%@ 1932-6203
%K SENEGAL
%M ISI:000310600500198
%N 10
%P e48684
%R 10.1371/journal.pone.0048684
%U https://www.documentation.ird.fr/hor/fdi:010058214
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-09/010058214.pdf
%V 7
%W Horizon (IRD)
%X Background: Pertussis, also known as whooping cough, is a vaccine-preventable respiratory disease caused by Bordetella pertussis infection, against which Senegalese children are immunized with the diphtheria-tetanus-whole cell pertussis vaccine (DTwP). Seroepidemiology of pertussis has been widely described in industrialized countries, but rare are the studies referring to it in developing countries. Methods: We conducted a longitudinal survey in Northern Senegal to investigate the epidemiology of B. pertussis by evaluating the IgG antibody (Ab) response against pertussis toxin (PT). A cohort of 410 children aged 1 to 9 from five villages in the Middle Senegal River Valley were followed-up for 18 months. During that period, five visits were made to assess the immunological status of the children. Principal Findings: PT-specific IgG responses were significantly different according to age. Until the age of 3, there was a decrease in the Ab response, which then increased in the older groups. Assessment of IgG antibodies to PT (IgG-PT) suggested evidence of recent exposures to the pathogen. Surprisingly, in one of the five villages the average Ab response to PT was very low at all ages during the first 6 months of the study. At the third visit, IgG-PT concentrations peaked to very high levels, to slightly decline at the end of the survey. This indicates an outbreak of B. pertussis, whereas in the other villages a pertussis endemic profile could be observed. Conclusions: Pertussis is endemic in Northern Senegal despite the introduction of vaccination. The circulation of the bacteria seems to differ between geographic locations and over time. A more complete understanding of the epidemiology of pertussis and its environmental determinants could provide information to adapt vaccination programs.
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