@article{fdi:010058214,
  title = {{S}eroprevalence of pertussis in {S}enegal : a prospective study},
  author = {{G}aayeb, {L}. and {S}arr, {J}. {B}. and {N}diath, {M}amadou and {H}anon, {J}. {B}. and {D}ebrie, {A}. {S}. and {S}eck, {M}. and {S}chacht, {A}. {M}. and {R}emou{\'e}, {F}ranck and {H}ermann, {E}. and {R}iveau, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {P}ertussis, also known as whooping cough, is a vaccine-preventable respiratory disease caused by {B}ordetella pertussis infection, against which {S}enegalese children are immunized with the diphtheria-tetanus-whole cell pertussis vaccine ({DT}w{P}). {S}eroepidemiology of pertussis has been widely described in industrialized countries, but rare are the studies referring to it in developing countries. {M}ethods: {W}e conducted a longitudinal survey in {N}orthern {S}enegal to investigate the epidemiology of {B}. pertussis by evaluating the {I}g{G} antibody ({A}b) response against pertussis toxin ({PT}). {A} cohort of 410 children aged 1 to 9 from five villages in the {M}iddle {S}enegal {R}iver {V}alley were followed-up for 18 months. {D}uring that period, five visits were made to assess the immunological status of the children. {P}rincipal {F}indings: {PT}-specific {I}g{G} responses were significantly different according to age. {U}ntil the age of 3, there was a decrease in the {A}b response, which then increased in the older groups. {A}ssessment of {I}g{G} antibodies to {PT} ({I}g{G}-{PT}) suggested evidence of recent exposures to the pathogen. {S}urprisingly, in one of the five villages the average {A}b response to {PT} was very low at all ages during the first 6 months of the study. {A}t the third visit, {I}g{G}-{PT} concentrations peaked to very high levels, to slightly decline at the end of the survey. {T}his indicates an outbreak of {B}. pertussis, whereas in the other villages a pertussis endemic profile could be observed. {C}onclusions: {P}ertussis is endemic in {N}orthern {S}enegal despite the introduction of vaccination. {T}he circulation of the bacteria seems to differ between geographic locations and over time. {A} more complete understanding of the epidemiology of pertussis and its environmental determinants could provide information to adapt vaccination programs.},
  keywords = {{SENEGAL}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {7},
  numero = {10},
  pages = {e48684},
  ISSN = {1932-6203},
  year = {2012},
  DOI = {10.1371/journal.pone.0048684},
  URL = {https://www.documentation.ird.fr/hor/fdi:010058214},
}