@article{fdi:010057515,
  title = {{F}irst molecular epidemiology study of {M}ycobacterium tuberculosis in {B}urkina {F}aso},
  author = {{G}odreuil, {S}ylvain and {T}orrea, {G}. and {T}erru, {D}. and {C}hevenet, {F}ran{\c{c}}ois and {D}iagbouga, {S}. and {S}upply, {P}. and {V}an de {P}erre, {P}. and {C}arri{\`e}re, {C}. and {B}anuls, {A}nne-{L}aure},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e conducted a molecular epidemiology study on 120 {M}ycobacterium tuberculosis isolates from patients presenting pulmonary tuberculosis ({TB}) in {B}urkina {F}aso. {C}lassical antibiogram studies and genetic characterization, using mycobacterial interspersed repetitive-unit-variable-number tandem-repeat ({MIRU}-{VNTR}) typing and spolligotyping, were applied after culture. {M}olecular analysis of specific signatures showed that all {TB} cases reported in this study were caused by {M}. tuberculosis and identified no {M}ycobacterium bovis or {M}ycobacterium africanum isolates. {T}his result is unexpected, as {M}. africanum strains were reportedly the etiologic agent in 20% of {TB} cases 2 decades ago. {T}he comparison of spoligotypes from {B}urkina {F}aso with an international spoligotype database ({S}po1{DB}4) showed that the majority of isolates belong to major clades of {M}. tuberculosis ({H}aarlem, 9%; {L}atin {A}merican-{M}editerranean, 30%; and {T}, 20%). {T}he predominant group of isolates (30%) corresponds to spoligotype 61, described in {C}ameroon as the "{C}ameroon family." {I}n {B}urkina {F}aso, as in {C}ameroon, this family could be associated with recent transmission of {TB}, suggesting a recent expansion in {W}est {A}frica. {O}ur data suggest a low level of primary drug resistance that may be a positive result of the {D}irectly {O}bserved {T}herapy {S}hortcourse program. {B}esides, based on spoligotyping plus {MIRU}-{VNTR}, data showed a high number of clusters in our sample, suggesting a high level of recent {TB} transmission in {B}urkina {F}aso. {N}evertheless, an important genetic polymorphism was observed in this country, reflecting an endemicity situation where the control of {TB} would have less impact in the main towns.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {C}linical {M}icrobiology},
  volume = {45},
  numero = {3},
  pages = {921--927},
  ISSN = {0095-1137},
  year = {2007},
  DOI = {10.1128/{JCM}.01918-06},
  URL = {https://www.documentation.ird.fr/hor/fdi:010057515},
}