@article{fdi:010057325,
  title = {{C}omparing the van {O}osterhout and {C}hybicki-{B}urczyk methods of estimating null allele frequencies for inbred populations},
  author = {{C}ampagne, {P}ascal and {S}mouse, {P}. {E}. and {V}arouchas, {G}. and {S}ilvain, {J}ean-{F}ran{\c{c}}ois and {L}e {R}ü, {B}runo},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n spite of the usefulness of codominant markers in population genetics, the existence of null alleles raises challenging estimation issues in natural populations that are characterized by positive inbreeding coefficients ({F}>0). {D}isregarding the possibility of {F}>0 in a population will generally lead to overestimates of null allele frequencies. {C}onversely, estimates of inbreeding coefficients ({F}) may be strongly biased upwards (excess homozygotes), in the presence of nontrivial frequencies of null alleles. {A}n algorithm has been presented for the estimation of null allele frequencies in inbred populations (van {O}osterhout method), using external estimates of the {F}-statistics. {T}he goal of this study is to introduce a modification of this method and to provide a formal comparison with an alternative likelihood-based method ({C}hybicki-{B}urczyk). {U}sing simulated data, we illustrate the strengths and limitations of these competing methods. {U}nder most circumstances, the likelihood method is preferable, but for highly inbred organisms, a modified van {O}osterhout method offers some advantages.},
  keywords = {heterozygote deficiency ; inbreeding coefficient ; null alleles},
  booktitle = {},
  journal = {{M}olecular {E}cology {R}esources},
  volume = {12},
  numero = {6},
  pages = {975--982},
  ISSN = {1755-098{X}},
  year = {2012},
  DOI = {10.1111/1755-0998.12015},
  URL = {https://www.documentation.ird.fr/hor/fdi:010057325},
}