Roche Benjamin auteur aut IRD Hochberg M. E. auteur aut IRD Caulin A. F. auteur aut IRD Maley C. C. auteur aut IRD Gatenby R. A. auteur aut IRD Missé Dorothée auteur aut IRD Thomas F. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Background: Peto's paradox stipulates that there is no association between body mass (a surrogate of number of cells and longevity) and cancer prevalence in wildlife species. Resolving this paradox is a very promising research direction to understand mechanisms of cancer resistance. As of present, research has been focused on the consequences of these evolutionary pressures rather than of their causes. Discussion: Here, we argue that evolution through natural selection may have shaped mechanisms of cancer resistance in wildlife species and that this can result in a threshold in body mass above which oncogenic and tumor suppressive mechanisms should be increasingly purified and positively selected, respectively. Summary: We conclude that assessing wildlife species in their natural ecosystems, especially through theoretical modeling, is the most promising way to understand how evolutionary processes can favor one or the other pathway. This will provide important insights into mechanisms of cancer resistance. specialized 050 020 12 387 2012 1471-2407 https://www.documentation.ird.fr/hor/fdi:010057318 10.1186/1471-2407-12-387 1471-2407 [F B010057318] https://www.documentation.ird.fr/hor/fdi:010057318 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-09/010057318.pdf IRD - Base Horizon / Pleins textes 2013-01-09 2020-03-17 fdi:010057318 fre