@article{fdi:010057308,
  title = {{A}dditional selection for insecticide resistance in urban malaria vectors : {DDT} resistance in {A}nopheles arabiensis from {B}obo-{D}ioulasso, {B}urkina {F}aso},
  author = {{J}ones, {C}. {M}. and {T}oe, {H}. {K}. and {S}anou, {A}. and {N}amountougou, {M}. and {H}ughes, {A}. and {D}iabate, {A}. and {D}abire, {R}. and {S}imard, {F}r{\'e}d{\'e}ric and {R}anson, {H}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n the city of {B}obo-{D}ioulasso in {B}urkina {F}aso, {A}nopheles arabiensis has superseded {A}nopheles gambiae s.s. as the major malaria vector and the larvae are found in highly polluted habitats normally considered unsuitable for {A}nopheles mosquitoes. {H}ere we show that {A}n. gambiae s.l. adults emerging from a highly polluted site in the city centre ({D}ioulassoba) have a high prevalence of {DDT} resistance (percentage mortality after exposure to diagnostic dose = 65.8% in the dry season and 70.4% in the rainy season, respectively). {A}n investigation into the mechanisms responsible found an unexpectedly high frequency of the 1014{S} kdr mutation (allele frequency = 0.4), which is found at very low frequencies in {A}n. arabiensis in the surrounding rural areas, and an increase in transcript levels of several detoxification genes, notably from the glutathione transferase and cytochrome {P}450 gene families. {A} number of {ABC} transporter genes were also expressed at elevated levels in the {DDT} resistant {A}n. arabiensis. {U}nplanned urbanisation provides numerous breeding grounds for mosquitoes. {T}he finding that {A}nopheles mosquitoes adapted to these urban breeding sites have a high prevalence of insecticide resistance has important implications for our understanding of the selective forces responsible for the rapid spread of insecticide resistant populations of malaria vectors in {A}frica.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {7},
  numero = {9},
  pages = {e45995},
  ISSN = {1932-6203},
  year = {2012},
  DOI = {10.1371/journal.pone.0045995},
  URL = {https://www.documentation.ird.fr/hor/fdi:010057308},
}