@article{fdi:010057280,
  title = {{A} novel rhabdovirus associated with acute hemorrhagic fever in {C}entral {A}frica},
  author = {{G}rard, {G}. and {F}air, {J}. {N}. and {L}ee, {D}. and {S}likas, {E}. and {S}teffen, {I}. and {M}uyembe, {J}. {J}. and {S}ittler, {T}. and {V}eeraraghavan, {N}. and {R}uby, {J}. {G}. and {W}ang, {C}. {L}. and {M}akuwa, {M}. and {M}ulembakani, {P}. and {T}esh, {R}. {B}. and {M}azet, {J}. and {R}imoin, {A}. {W}. and {T}aylor, {T}. and {S}chneider, {B}. {S}. and {S}immons, {G}. and {D}elwart, {E}. and {W}olfe, {N}. {D}. and {C}hiu, {C}. {Y}. and {L}eroy, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{D}eep sequencing was used to discover a novel rhabdovirus ({B}as-{C}ongo virus, or {BASV}) associated with a 2009 outbreak of 3 human cases of acute hemorrhagic fever in {M}angala village, {D}emocratic {R}epublic of {C}ongo ({DRC}), {A}frica. {T}he cases, presenting over a 3-week period, were characterized by abrupt disease onset, high fever, mucosal hemorrhage, and, in two patients, death within 3 days. {BASV} was detected in an acute serum sample from the lone survivor at a concentration of 1.09 x 10(6) {RNA} copies/m{L}, and 98.2% of the genome was subsequently de novo assembled from similar to 140 million sequence reads. {P}hylogenetic analysis revealed that {BASV} is highly divergent and shares less than 34% amino acid identity with any other rhabdovirus. {H}igh convalescent neutralizing antibody titers of >1:1000 were detected in the survivor and an asymptomatic nurse directly caring for him, both of whom were health care workers, suggesting the potential for human-to-human transmission of {BASV}. {T}he natural animal reservoir host or arthropod vector and precise mode of transmission for the virus remain unclear. {BASV} is an emerging human pathogen associated with acute hemorrhagic fever in {A}frica.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {P}athogens},
  volume = {8},
  numero = {9},
  pages = {e1002924},
  ISSN = {1553-7374},
  year = {2012},
  DOI = {10.1371/journal.ppat.1002924},
  URL = {https://www.documentation.ird.fr/hor/fdi:010057280},
}