@article{fdi:010057246,
  title = {{N}ew {STLV}-3 strains and a divergent {SIV}mus strain identified in non-human primate bushmeat in {G}abon},
  author = {{L}i{\'e}geois, {F}lorian and {B}oue, {V}. and {M}ouacha, {F}atima and {B}utel, {C}hristelle and {O}ndo, {B}. {M}. and {P}ourrut, {X}avier and {L}eroy, {E}ric and {P}eeters, {M}artine and {R}ouet, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {H}uman retroviral infections such as {H}uman {I}mmunodeficiency {V}irus ({HIV}) or {H}uman {T}-cell {L}ymphotropic {V}irus ({HTLV}) are the result of simian zoonotic transmissions through handling and butchering of {N}on-{H}uman {P}rimates ({NHP}) or by close contact with pet animals. {R}ecent studies on retroviral infections in {NHP} bushmeat allowed for the identification of numerous {S}imian {I}mmunodeficiency {V}iruses ({SIV}) and {S}imian {T}-cell {L}ymphotropic {V}iruses ({STLV}) to which humans are exposed. {N}evertheless, today, data on simian retroviruses at the primate/hunter interface remain scarce. {W}e conducted a pilot study on 63 blood and/or tissues samples derived from {NHP} bushmeat seized by the competent authorities in different locations across the country. {R}esults: {SIV} and {STLV} were detected by antibodies to {HIV} and {HTLV} antigens, and {PCR}s were performed on samples with an {HIV} or/and {HTLV}-like or indeterminate profile. {F}ourteen percent of the samples cross-reacted with {HIV} antigens and 44% with {HTLV} antigens. {W}e reported {STLV}-1 infections in five of the seven species tested. {STLV}-3 infections, including a new {STLV}-3 subtype, {STLV}-1 and -3 co-infections, and triple {SIV}, {STLV}-1, {STLV}-3 infections were observed in red-capped mangabeys ({C}.torquatus). {W}e confirmed {SIV} infections by {PCR} and sequence analyses in mandrills, red-capped mangabeys and showed that mustached monkeys in {G}abon are infected with a new {SIV} strain basal to the {SIV}gsn/mus/mon lineage that did not fall into the previously described {SIV}mus lineages reported from the corresponding species in {C}ameroon. {T}he same monkey (sub)species can thus be carrier of, at least, three distinct {SIV}s. {O}verall, the minimal prevalence observed for both {STLV} and {SIV} natural infections were 26.9% and 11.1% respectively. {C}onclusions: {O}verall, these data, obtained from a restricted sampling, highlight the need for further studies on simian retroviruses in sub-{S}aharan {A}frica to better understand their evolutionary history and to document {SIV} strains to which humans are exposed. {W}e also show that within one species, a high genetic diversity may exist for {SIV}s and {STLV}s and observe a high genetic diversity in the {SIV}gsn/mon/mus lineage, ancestor of {HIV}-1/{SIV}cpz/{SIV}gor.},
  keywords = {{SIV} ; {STLV} ; {N}on-{H}uman primate ; {Z}oonotic infections ; {B}ushmeat ; {G}abon},
  booktitle = {},
  journal = {{R}etrovirology},
  volume = {9},
  numero = {},
  pages = {28},
  ISSN = {1742-4690},
  year = {2012},
  DOI = {10.1186/1742-4690-9-28},
  URL = {https://www.documentation.ird.fr/hor/fdi:010057246},
}