@article{fdi:010057212,
  title = {{AUX}/{LAX} genes encode a family of auxin influx transporters that perform distinct functions during {A}rabidopsis development},
  author = {{P}eret, {B}. and {S}warup, {K}. and {F}erguson, {A}. and {S}eth, {M}. and {Y}ang, {Y}. {D}. and {D}hondt, {S}. and {J}ames, {N}. and {C}asimiro, {I}. and {P}erry, {P}. and {S}yed, {A}. and {Y}ang, {H}. {B}. and {R}eemmer, {J}. and {V}enison, {E}. and {H}owells, {C}. and {P}erez-{A}mador, {M}. {A}. and {Y}un, {J}. {G}. and {A}lonso, {J}. and {B}eemster, {G}. {T}. {S}. and {L}aplaze, {L}aurent and {M}urphy, {A}. and {B}ennett, {M}. {J}. and {N}ielsen, {E}. and {S}warup, {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}uxin transport, which is mediated by specialized influx and efflux carriers, plays a major role in many aspects of plant growth and development. {AUXIN}1 ({AUX}1) has been demonstrated to encode a high-affinity auxin influx carrier. {I}n {A}rabidopsis thaliana, {AUX}1 belongs to a small multigene family comprising four highly conserved genes (i.e., {AUX}1 and {LIKE} {AUX}1 [{LAX}] genes {LAX}1, {LAX}2, and {LAX}3). {W}e report that all four members of this {AUX}/{LAX} family display auxin uptake functions. {D}espite the conservation of their biochemical function, {AUX}1, {LAX}1, and {LAX}3 have been described to regulate distinct auxin-dependent developmental processes. {H}ere, we report that {LAX}2 regulates vascular patterning in cotyledons. {W}e also describe how regulatory and coding sequences of {AUX}/{LAX} genes have undergone subfunctionalization based on their distinct patterns of spatial expression and the inability of {LAX} sequences to rescue aux1 mutant phenotypes, respectively. {D}espite their high sequence similarity at the protein level, transgenic studies reveal that {LAX} proteins are not correctly targeted in the {AUX}1 expression domain. {D}omain swapping studies suggest that the {N}-terminal half of {AUX}1 is essential for correct {LAX} localization. {W}e conclude that {A}rabidopsis {AUX}/{LAX} genes encode a family of auxin influx transporters that perform distinct developmental functions and have evolved distinct regulatory mechanisms.},
  keywords = {},
  booktitle = {},
  journal = {{P}lant {C}ell},
  volume = {24},
  numero = {7},
  pages = {2874--2885},
  ISSN = {1040-4651},
  year = {2012},
  DOI = {10.1105/tpc.112.097766},
  URL = {https://www.documentation.ird.fr/hor/fdi:010057212},
}