@article{fdi:010057167,
  title = {{R}ecent introduction and rapid dissemination of chikungunya virus and dengue virus serotype 2 associated with human and mosquito coinfections in {G}abon, {C}entral {A}frica},
  author = {{C}aron, {M}. and {P}aupy, {C}hristophe and {G}rard, {G}. and {B}ecquart, {P}ierre and {M}ombo, {I}. and {N}so, {B}. {B}. {B}. and {K}assa, {F}. {K}. and {N}koghe, {D}. and {L}eroy, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {C}hikungunya virus ({CHIKV}) and {D}engue virus serotype 2 ({DENV}-2) were recently introduced in central {A}frica, along with {A}edes albopictus. {S}imultaneous outbreaks of {CHIKV} and {DENV}-2 have subsequently occurred, in {C}ameroon in 2006 and {G}abon in 2007. {M}ethods. {T}o study the spread of the 2 viruses, we conducted active surveillance of acute febrile syndromes throughout {G}abon between 2007 and 2010. {D}iagnostic methods included quantitative real-time reverse-transcription polymerase chain reaction, and molecular characterization was based on partial envelope gene sequences. {R}esults. {B}etween 2007 and 2010, 4287 acutely febrile patients were investigated for {CHIKV} and {DENV}-2 infections, of whom 1567 were {CHIKV}-positive, 376 {DENV}-2-positive, and 37 coinfected. {W}e diagnosed 153 {CHIKV} and 11 {DENV}-2 cases in 2008, and 5 {CHIKV} and 9 {DENV}-2 cases in 2009. {I}n 2010, {CHIKV} and {DENV}-2 caused a second large simultaneous outbreak. {A}mong 2826 acutely febrile patients examined during this outbreak, 1112 were {CHIKV}-positive, 288 {DENV}-2-positive, and 28 coinfected. {M}osquitoes were collected near the homes of coinfected patients, and 1 {A}edes albopictus specimen was found to be positive for both {CHIKV} and {DENV}-2. {C}onclusions. {T}hese findings show the rapid dissemination of {CHIKV} and {DENV}-2 within a nonimmune population in a tropical {A}frican country, probably facilitated by the spread of {A}edes albopictus. {T}his has resulted in major simultaneous outbreaks with numerous coinfections in both human and mosquito.},
  keywords = {},
  booktitle = {},
  journal = {{C}linical {I}nfectious {D}iseases},
  volume = {55},
  numero = {6},
  pages = {{E}45--{E}53},
  ISSN = {1058-4838},
  year = {2012},
  DOI = {10.1093/cid/cis530},
  URL = {https://www.documentation.ird.fr/hor/fdi:010057167},
}