@article{fdi:010057163, title = {{C}utaneous manifestations of filovirus infections}, author = {{N}koghe, {D}. and {L}eroy, {E}ric and {T}oung-{M}ve, {M}. and {G}onzalez, {J}ean-{P}aul}, editor = {}, language = {{ENG}}, abstract = {{E}bolavirus and {M}arburgvirus, two filoviruses belonging to the {F}iloviridae family, are among the most virulent pathogens for humans and non-human primates, causing outbreaks of fulminant hemorrhagic fever ({HF}) in {C}entral {A}frican countries with case fatality rates of up to 90%. {F}ruit bats are the likely reservoir, and human infection occurs through contact with bats or infected large-animal carcasses or by person-to-person contact (through body fluids, medical care, and burial practices). {S}chematically, clinical manifestations occur in three successive phases and include general, gastrointestinal, and mucocutaneous disorders. {D}eath usually results from hemorrhagic complications. {C}utaneous manifestations rarely make a major contribution to disease severity but can assist with the diagnosis. {R}ash, the main cutaneous disorder, is nonspecific and cannot guide the differential diagnosis. {I}mmunohistochemical examination of skin biopsy or necropsy specimens can confirm the diagnosis.}, keywords = {}, booktitle = {}, journal = {{I}nternational {J}ournal of {D}ermatology}, volume = {51}, numero = {9}, pages = {1037--1043}, ISSN = {0011-9059}, year = {2012}, DOI = {10.1111/j.1365-4632.2011.05379.x}, URL = {https://www.documentation.ird.fr/hor/fdi:010057163}, }