%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Monleau, Marjorie
%A Aghokeng Fobang, Avelin
%A Nkano, B.A.
%A Chaix, M.L.
%A Peeters, Martine
%T Drug resistance mutations of HIV type 1 non-B viruses to integrase inhibitors in treatment-naive patients from sub-Saharan countries and discordant interpretations
%D 2012
%L fdi:010057154
%G ENG
%J Aids Research and Human Retroviruses
%@ 0889-2229
%M ISI:000308337300030
%N 9
%P 957-960
%R 10.1089/aid.2011.0326
%U https://www.documentation.ird.fr/hor/fdi:010057154
%> https://www.documentation.ird.fr/intranet/publi/2012/09/010057154.pdf
%V 28
%W Horizon (IRD)
%X The routine use of integrase inhibitors in sub-Saharan Africa where HIV-1 non-B viruses predominate is limited, but evaluating their effectiveness on HIV-1 subtypes and CRFs that circulate in this region is essential. We here analyzed 97 integrase sequences from HIV-1 non-B-infected individuals from African countries. Using currently available interpretation algorithms (ANRS, FTIVdb, and Rega), we identified the presence of mutations at nine resistance-associated positions including L74M (3.1%), T97A (9.3%), K156N (2.1%), E157Q (5.2%), G163K (1.0%), T206S (48.5%), S230N (1.0%), D232N (1.0%), and R236K (1.0%). All but one (E157Q) were considered as accessory resistant mutation by the algorithms. E157Q identified in 5% of patients tested (5/97) was selected by the ANRS algorithm as a primary mutation, which alone can confer resistance to raltegravir. These results illustrated the need of further in vitro and clinical studies involving non-B viruses to better understand the real significance of observed mutations and harmonize interpretations.
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