@article{fdi:010057153, title = {{A}ntiplasmodial and leishmanicidal activities of 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives}, author = {{B}area, {C}. and {P}abon, {A}. and {G}aliano, {S}. and {P}erez-{S}ilanes, {S}. and {G}onzalez, {G}. and {D}eyssard, {C}. and {M}onge, {A}. and {D}eharo, {E}ric and {A}ldana, {I}.}, editor = {}, language = {{ENG}}, abstract = {{M}alaria and leishmaniasis are two of the {W}orld's most important tropical parasitic diseases. {T}hirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives ({CPCQ}s) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against erythrocytic forms of {P}lasmodium falciparum and axenic forms of {L}eishmania infantum. {T}heir toxicity against {VERO} cells (normal monkey kidney cells) was also assessed. {N}one of the tested compounds was efficient against {P}lasmodium, but two of them showed good activity against {L}eishmania. {T}oxicity on {VERO} was correlated with leishmanicidal properties.}, keywords = {quinoxaline ; piperazine ; {P}lasmodium ; {L}eishmania ; {VERO}}, booktitle = {}, journal = {{M}olecules}, volume = {17}, numero = {8}, pages = {9451--9461}, ISSN = {1420-3049}, year = {2012}, DOI = {10.3390/molecules17089451}, URL = {https://www.documentation.ird.fr/hor/fdi:010057153}, }