@article{fdi:010057080,
  title = {{D}ifferential acquisition of human antibody responses to {P}lasmodium falciparum according to intensity of exposure to {A}nopheles bites},
  author = {{S}arr, {J}. {B}. and {S}amb, {B}. and {S}agna, {A}. {B}. and {F}ortin, {S}. and {D}oucour{\'e}, {S}ouleymane and {S}ow, {C}. and {S}enghor, {S}. and {G}aayeb, {L}. and {G}uindo, {S}. and {S}chacht, {A}. {M}. and {R}ogerie, {F}. and {H}ermann, {E}. and {D}ia, {I}. and {K}onat{\'e}, {L}. and {R}iveau, {G}. and {R}emou{\'e}, {F}ranck},
  editor = {},
  language = {{ENG}},
  abstract = {{M}alaria immunity is modulated by many environmental and epidemiological factors. {T}his study evaluates the influence of a hitherto unstudied environmental-epidemiological factor, namely the impact of human exposure to {A}nopheles bites on the isotype profile of acquired antibody responses to {P}lasmodium falciparum. {I}n two {S}enegalese villages where the intensity of exposure to {A}nopheles bites was markedly different (high and low exposure), specific {I}g{G}1 and {I}g{G}3 responses to {P}. falciparum whole schizont extract ({WSE}) and circumsporozoite protein ({CSP}) were evaluated at the peak of {A}nopheles exposure ({S}eptember) and later ({D}ecember) in a cohort of 120 children aged 3-8 years. {M}ultivariate analysis showed a significantly lower {I}g{G}1 response against {P}. falciparum {WSE} and {CSP} in children highly exposed to {A}nopheles bites ({G}ankette) compared to those who were weakly exposed ({M}boula). {I}n contrast, in both villages, parasitemia and increasing age were strongly associated with higher {I}g{G}1 and {I}g{G}3 levels. {W}e hypothesize that high exposure to {A}nopheles bites could inhibit {I}g{G}1-dependent responsiveness to {P}. falciparum known to induce protective immune responses against malaria. {T}he impact of mosquito saliva on the regulation of specific protective immunity may need to be taken into account in epidemiological studies and trials for malaria vaccines.},
  keywords = {{M}alaria ; {I}mmunity ; {A}nopheles exposure ; {A}ntibody ; {I}mmunomodulation},
  booktitle = {},
  journal = {{T}ransactions of the {R}oyal {S}ociety of {T}ropical {M}edicine and {H}ygiene},
  volume = {106},
  numero = {8},
  pages = {460--467},
  ISSN = {0035-9203},
  year = {2012},
  DOI = {10.1016/j.trstmh.2012.05.006},
  URL = {https://www.documentation.ird.fr/hor/fdi:010057080},
}