Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge #Homophymia $sp.

Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge #Homophymia $sp. Zampella A. auteur aut IRD Sepe V. auteur aut IRD Bellotta F. auteur aut IRD Luciano P. auteur aut IRD D'Auria M. V. auteur aut IRD Cresteil T. auteur aut IRD Debitus Cécile auteur aut IRD Petek Sylvain auteur aut IRD Poupat C. auteur aut IRD Ahond A. auteur aut IRD text journalArticle eng text/pdf born digital access Nine new cyclodepsipeptides, homophymines B-E (2-5) and A1-E1 (1a-5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC50 in the nM range) against a panel of human cancer cell lines. specialized 035 Organic and Biomolecular Chemistry 7 19 4037-4044 2009 1477-0520 https://www.documentation.ird.fr/hor/fdi:010056917 10.1039/b910015f 1477-0520 [F B010056917] https://www.documentation.ird.fr/hor/fdi:010056917 https://www.documentation.ird.fr/intranet/publi/depot/2012-09-11/010056917.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2009-11-09 2017-08-23 fdi:010056917 fre