Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp. Organic and Biomolecular Chemistry 4037-4044 2009 fdi:010056917 ENG Organic and Biomolecular Chemistry 1477-0520 ISI:000269892900022 19 10.1039/b910015f https://www.documentation.ird.fr/hor/fdi:010056917 https://www.documentation.ird.fr/intranet/publi/depot/2012-09-11/010056917.pdf 7 Horizon (IRD) Nine new cyclodepsipeptides, homophymines B-E (2-5) and A1-E1 (1a-5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC50 in the nM range) against a panel of human cancer cell lines. 035 UR148 / UR152