Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp. Zampella, A. Sepe, V. Bellotta, F. Luciano, P. D'Auria, M. V. Cresteil, T. /Debitus, Cécile /Petek, Sylvain Poupat, C. Ahond, A. Nine new cyclodepsipeptides, homophymines B-E (2-5) and A1-E1 (1a-5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC50 in the nM range) against a panel of human cancer cell lines. 2009 text https://www.documentation.ird.fr/hor/fdi:010056917 fdi:010056917 Zampella A., Sepe V., Bellotta F., Luciano P., D'Auria M. V., Cresteil T., Debitus Cécile, Petek Sylvain, Poupat C., Ahond A.. Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.. 2009, 7 (19), 4037-4044 EN