@article{fdi:010056619,
  title = {{L}evocetirizine for treatment of immediate and delayed mosquito bite reactions},
  author = {{K}arppinen, {A}. and {B}rummer {K}orvenkontio, {H}. and {P}etman, {L}. and {K}autiainen, {H}. and {H}erv{\'e}, {J}ean-{P}ierre and {R}eunala, {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}eople frequently experience whealing and delayed papules from mosquito bites. {V}arious antihistamines have previously been tried for the treatment of this condition. {W}e performed a double-blind, placebo-controlled, crossover study with levocetirizine 5 mg and matched placebo in 30 adults who were sensitive to mosquito bites. {O}n the third treatment day the subjects received two {A}edes aegypti bites on the forearm. {T}he size of the bite lesions and the intensity of pruritus (visual analogue scale) were measured. {B}ite symptoms could be analysed in 28 subjects at 15 min and in 8 subjects at 24 h. {L}evocetirizine decreased the size of wheals by 60% (p <0.001) and accompanying pruritus by 62% (p <0.001) compared with placebo. {T}he effect of levocetirizine increased in a linear fashion with the size of wheals and was most significant in the subjects with largest bite lesions. {L}evocetirizine also decreased the size of 24-h bite lesions by 71% (p=0.008) and accompanying pruritus by 56% (p=0.016). {T}hese results show that prophylactic levocetirizine 5 mg is an effective treatment for both immediate and delayed mosquito bite symptoms and is especially effective in subjects with large wheals.},
  keywords = {mosquito allergy ; antihistamine ; levocetirizine ; wheal ; delayed bite lesion ; pruritus},
  booktitle = {},
  journal = {{A}cta {D}ermato {V}enereologica},
  volume = {86},
  numero = {4},
  pages = {329--331},
  ISSN = {0001-5555},
  year = {2006},
  DOI = {10.2340/00015555-0085},
  URL = {https://www.documentation.ird.fr/hor/fdi:010056619},
}