@article{fdi:010055975,
  title = {{C}onsequences of gestational malaria on birth weight : finding the best timeframe for intermittent preventive treatment administration},
  author = {{H}uynh, {B}ich-{T}ram and {F}ievet, {N}adine and {B}riand, {V}al{\'e}rie and {B}orgella, {S}ophie and {M}assougbodji, {A}. and {D}eloron, {P}hilippe and {C}ot, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{T}o investigate the consequences of intermittent preventive treatment ({IPT}p) timing on birth weight, we pooled data from two studies conducted in {B}enin between 2005 and 2010: a prospective cohort of 1037 pregnant women and a randomised trial comparing sulfadoxine-pyrimethamine ({SP}) to mefloquine in 1601 women. {A} total of 1439 women (752 in the cohort and 687 in the {SP} arm of the randomised trial) who delivered live singletons were analysed. {W}e showed that an early intake of the first {SP} dose (4 months of gestation) was associated with a lower risk of {LBW} compared to a late intake (6-7 months of gestation) (a{OR} = 0.5 p = 0.01). {W}e also found a borderline increased risk of placental infection when the first {SP} dose was administered early in pregnancy (a{OR} = 1.7 p = 0.1). {T}his study is the first to investigate the timing of {SP} administration during pregnancy. {W}e clearly demonstrated that women who had an early intake of the first {SP} dose were less at risk of {LBW} compared to those who had a late intake. {P}regnant women should be encouraged to attend antenatal visits early to get their first {SP} dose and a third dose of {SP} could be recommended to cover the whole duration of pregnancy and to avoid late infections of the placenta.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {7},
  numero = {4},
  pages = {e35342},
  ISSN = {1932-6203},
  year = {2012},
  DOI = {10.1371/journal.pone.0035342},
  URL = {https://www.documentation.ird.fr/hor/fdi:010055975},
}