@article{fdi:010055933,
  title = {{H}ost cell/{O}rientia tsutsugamushi interactions : evolution and expression of syndecan-4 in {A}sian rodents ({R}odentia, {M}uridae)},
  author = {{B}adenhorst, {D}. and {T}atard, {C}. and {S}uputtamongkol, {Y}. and {R}obinson, {T}. {J}. and {D}obigny, {G}authier},
  editor = {},
  language = {{ENG}},
  abstract = {{S}crub typhus is an acute febrile zoonotic disease and worldwide more than a billion people may be at risk for infection. {O}rientia tsutsugamushi, the causative agent of scrub typhus, is an obligate intracellular bacterium. {R}odents are reported to be the primary reservoir hosts of the disease and according to the most recent surveys, all species within the {R}attus sensu lato complex of the tribe {R}attini are carriers of scrub typhus. {T}here is no evidence that any of mouse ({M}us) species serves as the primary reservoir of the bacterium even when occurring in sympatry with wild infected rats. {T}his contrast in the host/syndecan-4 interactions between {R}attini and {A}sian {M}urini may be due to intrinsic (i.e., genetic) differences. {H}erein we compare the sequence and expression levels of syndecan-4 (the putative cell receptor of {O}. tsutsugamushi) between {R}attini species that are known to be natural reservoirs for the typhus agents, and {M}urini species that are not. {A}lthough it was not possible to conclusively link the structural variations detected in syndecan-4 with carrier status in either {R}attini and {M}urini, our findings indicate the absence of a strong {O}rientia-mediated selective regime acting on gene structure. {I}n contrast, variable spleen-specific syndecan-4 expression levels show a strong correlation between under-expression of syndecan-4 in {M}urini and seropositive {R}attini, compared to seronegative {R}attini rodents. {W}e postulate that two divergent responses may be at work in {M}urini and {R}attini, both linked with differential expression of syndecan-4: (i) reduced syndecan-4 transcription in {M}urini decreases the likelihood that the host cells will become infected by the {O}rientia bacterium, while (ii) reduced syndecan-4 expression in seropositive {R}attini limits the pathogenicity of {O}rientia and consequently improves the longevity of the rat hosts. {T}hese patterns may underpin the poor carrier status of wild mice on the one hand, and the effective role of wild rats as reservoir hosts on the other.},
  keywords = {{Z}oonotic disease ; {S}crub typhus ; {O}rientia tsutsugamushi ; {S}yndecan-4 ; {R}attini ; {M}urini},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {12},
  numero = {5},
  pages = {1136--1146},
  ISSN = {1567-1348},
  year = {2012},
  DOI = {10.1016/j.meegid.2012.03.020},
  URL = {https://www.documentation.ird.fr/hor/fdi:010055933},
}