Sorres J. auteur aut IRD Martin M. T. auteur aut IRD Petek Sylvain auteur aut IRD Levaique H. auteur aut IRD Cresteil T. auteur aut IRD Ramos S. auteur aut IRD Thoison O. auteur aut IRD Debitus Cécile auteur aut IRD Al-Mourabit A. auteur aut IRD text journalArticle eng text/pdf born digital access Pipestelides A-C (2-4) are three new NRPS-PKS hybrid macrolides containing uncommon moieties, isolated from the Pacific marine sponge Pipestela candelabra. Their structures were elucidated on the basis of spectroscopic data. These cyclodepsipeptides appear to be biosynthetically related to jaspamide (aka jasplakinolide) (1) by chemical modification of the building blocks of the polyketide or peptide chains. Pipestelides A-C (2-4) contain a bromotyrosine [3-amino-3-(bromo-4-hydroxyphenyl)propanoic acid] unit, a polypropionate with a Z double bond, and a 2-hydroxyquinolinone, respectively. Revised chemical shift assignments are provided for the co-isolated known jasplakinolide C-a (5). In addition, compounds 2 and 3 exhibited cytotoxic activities in the micromolar range. specialized 035 75 4 759-763 2012 0163-3864 https://www.documentation.ird.fr/hor/fdi:010055866 10.1021/np200714m 0163-3864 [F B010055866] https://www.documentation.ird.fr/hor/fdi:010055866 https://www.documentation.ird.fr/intranet/publi/2012/05/010055866.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2012-06-01 2017-08-23 fdi:010055866 fre