@article{fdi:010055852,
  title = {{I}g{G} responses to the g{SG}6-{P}1 salivary peptide for evaluating human exposure to {A}nopheles bites in urban areas of {D}akar region, {S}enegal},
  author = {{D}ram{\'e}, {P}apa {M}aktar and {M}achault, {V}. and {D}iallo, {A}. and {C}orn{\'e}lie, {S}ylvie and {P}oinsignon, {A}nne and {L}alou, {R}ichard and {S}embene, {M}. and {D}os {S}antos, {S}t{\'e}phanie and {R}ogier, {C}. and {P}ag{\`e}s, {F}. and {L}e {H}esran, {J}ean-{Y}ves and {R}emou{\'e}, {F}ranck},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {U}rban malaria can be a serious public health problem in {A}frica. {H}uman-landing catches of mosquitoes, a standard entomological method to assess human exposure to malaria vector bites, can lack sensitivity in areas where exposure is low. {A} simple and highly sensitive tool could be a complementary indicator for evaluating malaria exposure in such epidemiological contexts. {T}he human antibody response to the specific {A}nopheles g{SG}6-{P}1 salivary peptide have been described as an adequate tool biomarker for a reliable assessment of human exposure level to {A}nopheles bites. {T}he aim of this study was to use this biomarker to evaluate the human exposure to {A}nopheles mosquito bites in urban settings of {D}akar ({S}enegal), one of the largest cities in {W}est {A}frica, where {A}nopheles biting rates and malaria transmission are supposed to be low. {M}ethods: {O}ne cross-sectional study concerning 1,010 (505 households) children (n = 505) and adults (n = 505) living in 16 districts of downtown {D}akar and its suburbs was performed from {O}ctober to {D}ecember 2008. {T}he {I}g{G} responses to g{SG}6-{P}1 peptide have been assessed and compared to entomological data obtained in or near the same district. {R}esults: {C}onsiderable individual variations in anti-g{SG}6-{P}1 {I}g{G} levels were observed between and within districts. {I}n spite of this individual heterogeneity, the median level of specific {I}g{G} and the percentage of immune responders differed significantly between districts. {A} positive and significant association was observed between the exposure levels to {A}nopheles gambiae bites, estimated by classical entomological methods, and the median {I}g{G} levels or the percentage of immune responders measuring the contact between human populations and {A}nopheles mosquitoes. {I}nterestingly, immunological parameters seemed to better discriminate the exposure level to {A}nopheles bites between different exposure groups of districts. {C}onclusions: {S}pecific human {I}g{G} responses to g{SG}6-{P}1 peptide biomarker represent, at the population and individual levels, a credible new alternative tool to assess accurately the heterogeneity of exposure level to {A}nopheles bites and malaria risk in low urban transmission areas. {T}he development of such biomarker tool would be particularly relevant for mapping and monitoring malaria risk and for measuring the efficiency of vector control strategies in these specific settings.},
  keywords = {{SENEGAL}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {11},
  numero = {},
  pages = {72},
  ISSN = {1475-2875},
  year = {2012},
  DOI = {10.1186/1475-2875-11-72},
  URL = {https://www.documentation.ird.fr/hor/fdi:010055852},
}