@article{fdi:010055824,
  title = {4-{M}ethylenesterols from {T}heonella swinhoei sponge are natural pregnane-{X}-receptor agonists and farnesoid-{X}-receptor antagonists that modulate innate immunity},
  author = {{D}e {M}arino, {S}. and {U}mmarino, {R}. and {D}'{A}uria, {M}. {V}. and {C}hini, {M}. {G}. and {B}ifulco, {G}. and {D}'{A}more, {C}. and {R}enga, {B}. and {M}encarelli, {A}. and {P}etek, {S}ylvain and {F}iorucci, {S}. and {Z}ampella, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e report the isolation and the structural elucidation of a family of polyhydroxylated steroids from the marine sponge {T}heonella swinhoei. {D}ecodification of interactions of these family with nuclear receptors shows that these steroids are potent agonists of human pregnane-{X}-receptor ({PXR}) and antagonists of human farnesoid-{X}-receptor ({FXR}) with the putative binding mode to nuclear receptors ({NR}s) obtained through docking experiments. {B}y using monocytes isolated from transgenic mice harboring h{PXR}. we demonstrated that swinhosterol {B} counter-regulates induction of pro-inflammatory cytokines in a {PXR}-dependent manner. {E}xposure of {CD}4(+) {T} cells to swinhosterol {B} upregulates the expression of {IL}-10 causing a shift toward a {T} cells regulatory phenotype in a {PXR} dependent manner. {T}hese results pave the way to development of a dual {PXR} agonist/{FXR} antagonist with a robust immunomodulatory activity and endowed with the ability to modulate the expression of bile acid-regulated genes in the liver.},
  keywords = {{M}arine sponge ; {T}heonella swinhoei ; {N}uclear receptors ; {F}arnesoid-{X}-receptor ; {P}regnane-{X}-receptor},
  booktitle = {},
  journal = {{S}teroids},
  volume = {77},
  numero = {5},
  pages = {484--495},
  ISSN = {0039-128{X}},
  year = {2012},
  DOI = {10.1016/j.steroids.2012.01.006},
  URL = {https://www.documentation.ird.fr/hor/fdi:010055824},
}