@article{fdi:010055813,
  title = {{A}symptomatic carriage of plasmodium in urban {D}akar : the risk of malaria should not be underestimated},
  author = {{D}iallo, {A}. and {T}uikue {N}dam, {N}icaise and {M}oussiliou, {A}. and {D}os {S}antos, {S}t{\'e}phanie and {N}donky, {A}lphousseyni and {B}orderon, {M}. and {O}liveau, {S}. and {L}alou, {R}ichard and {L}e {H}esran, {J}ean-{Y}ves},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction: {T}he objective of this study was to measure the rate of asymptomatic carriage of plasmodium in the {D}akar region two years after the implementation of new strategies in clinical malaria management. {M}ethodology: {B}etween {O}ctober and {D}ecember 2008, 2952 households selected in 50 sites of {D}akar area, were visited for interviews and blood sampling. {G}iemsa-stained thick blood smears ({TBS}) were performed for microscopy in asymptomatic adult women and children aged 2 to 10 years. {T}o ensure the quality of the microscopy, we performed a polymerase chain reaction ({PCR}) with real time q{PCR} in all positive {TBS} by microscopy and in a sample of negative {TBS} and filter paper blood spots. {R}esults: {T}he analysis has concerned 2427 women and 2231 children. {T}he mean age of the women was 35.6 years. {T}he mean age of the children was 5.4 years. {T}he parasite prevalence was 2.01% (49/2427) in women and 2.15% (48/2231) in children. {P}arasite prevalence varied from one study site to another, ranging from 0 to 7.41%. {I}n multivariate analysis, reporting a malaria episode in 2008 was associated with plasmodium carriage ({OR} = 2.57, {P} = 0.002) in women; in children, a malaria episode ({OR} = 6.19, {P} < 0.001) and a travel out of {D}akar during last 3 months ({OR} = 2.27, {P} = 0.023) were associated with plasmodium carriage. {A}mong the positive {TBS}, 95.8% (93/97) were positive by plasmodium {PCR}. {A}mong the negative {TBS}, 13.9% (41/293) were positive by {PCR}. {I}n blood spots, 15.2% (76/500) were positive by {PCR}. {W}e estimated at 16.5% the parasite prevalence if {PCR} were performed in 4658 {TBS}. {C}onclusion: {P}arasite prevalence in {D}akar area seemed to be higher than the rate found by microscopy. {PCR} may be the best tool for measuring plasmodium prevalence in the context of low transmission. {E}nvironmental conditions play a major role in the heterogeneity of parasite prevalence within sites.},
  keywords = {{SENEGAL} ; {DAKAR}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {7},
  numero = {2},
  pages = {e31100},
  ISSN = {1932-6203},
  year = {2012},
  DOI = {10.1371/journal.pone.0031100},
  URL = {https://www.documentation.ird.fr/hor/fdi:010055813},
}