@article{fdi:010055785,
  title = {{L}oss of {DNA} methylation affects the recombination landscape in {A}rabidopsis},
  author = {{M}irouze, {M}arie and {L}ieberman-{L}azarovich, {M}. and {A}versano, {R}. and {B}ucher, {E}. and {N}icolet, {J}. and {R}einders, {J}. and {P}aszkowski, {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{D}uring sexual reproduction, one-half of the geneticmaterial is deposited in gametes, and a complete set of chromosomes is restored upon fertilization. {R}eduction of the genetic information before gametogenesis occurs in meiosis, when cross-overs ({CO}s) between homologous chromosomes secure an exchange of their genetic information. {CO}s are not evenly distributed along chromosomes and are suppressed in chromosomal regions encompassing compact, hypermethylated centromeric and pericentromeric {DNA}. {T}herefore, it was postulated that {DNA} hypermethylation is inhibitory to {CO}s. {H}ere, when analyzing meiotic recombination in mutant plants with hypomethylated {DNA}, we observed unexpected and counterintuitive effects of {DNA} methylation losses on {CO} distribution. {R}ecombination was further promoted in the hypomethylated chromosome arms while it was inhibited in heterochromatic regions encompassing pericentromeric {DNA}. {I}mportantly, the total number of {CO}s was not affected, implying that loss of {DNA} methylation led to a global redistribution of {CO}s along chromosomes. {T}o determine by which mechanisms altered levels of {DNA} methylation influence recombination-whether directly in cis or indirectly in trans by changing expression of genes encoding recombination components-we analyzed {CO} distribution in wild-type lines with randomly scattered and well-mapped hypomethylated chromosomal segments. {T}he results of these experiments, supported by expression profiling data, suggest that {DNA} methylation affects meiotic recombination in cis. {B}ecause {DNA} methylation exhibits significant variation even within a single species, our results imply that it may influence the evolution of plant genomes through the control of meiotic recombination.},
  keywords = {epigenetic ; chromatin ; epigenetic recombinant inbred lines ; met1-3},
  booktitle = {},
  journal = {{P}roceedings of the {N}ational {A}cademy of {S}ciences of the {U}nited {S}tates of {A}merica},
  volume = {109},
  numero = {15},
  pages = {5880--5885},
  ISSN = {0027-8424},
  year = {2012},
  DOI = {10.1073/pnas.1120841109},
  URL = {https://www.documentation.ird.fr/hor/fdi:010055785},
}