@article{fdi:010055719,
  title = {{E}volution of the primate apobec3a cytidine deaminase gene and identification of related coding regions},
  author = {{H}enry, {M}. and {T}erzian, {C}. and {P}eeters, {M}artine and {W}ain-{H}obson, {S}. and {V}artanian, {J}. {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he {APOBEC}3 gene cluster encodes six cytidine deaminases ({A}3{A}-{C}, {A}3{DE}, {A}3{F}-{H}) with single stranded {DNA} (ss{DNA}) substrate specificity. {F}or the moment {A}3{A} is the only enzyme that can initiate catabolism of both mitochondrial and nuclear {DNA}. {H}uman {A}3{A} expression is initiated from two different methionine codons {M}1 or {M}13, both of which are in adequate but sub-optimal {K}ozak environments. {I}n the present study, we have analyzed the genetic diversity among {A}3{A} genes across a wide range of 12 primates including {N}ew {W}orld monkeys, {O}ld {W}orld monkeys and {H}ominids. {S}equence variation was observed in exons 1-4 in all primates with up to 31% overall amino acid variation. {I}mportantly for 3 hominids codon {M}1 was mutated to a threonine codon or valine codon, while for 5/12 primates strong {K}ozak {M}1 or {M}13 codons were found. {P}ositive selection was apparent along a few branches which differed compared to positive selection in the carboxy-terminal of {A}3{G} that clusters with {A}3{A} among human cytidine deaminases. {I}n the course of analyses, two novel non-functional {A}3{A}-related fragments were identified on chromosome 4 and 8 kb upstream of the {A}3 locus. {T}his qualitative and quantitative variation among primate {A}3{A} genes suggest that subtle differences in function might ensue as more light is shed on this increasingly important enzyme.},
  keywords = {},
  booktitle = {},
  journal = {{P}lo{S} {O}ne},
  volume = {7},
  numero = {1},
  pages = {art. e30036},
  ISSN = {1932-6203},
  year = {2012},
  DOI = {10.1371/journal.pone.0030036},
  URL = {https://www.documentation.ird.fr/hor/fdi:010055719},
}