@article{fdi:010055697, title = {{D}evelopment of trichosomoides nasalis (nematoda: trichinelloidea) in the murid host: evidence for larval growth in striated muscle fibres}, author = {{F}all, {E}.{H}. and {D}iagne, {M}. and {J}unker, {K}. and {D}uplantier, {J}ean-{M}arc and {B}a, {K}. and {V}all{\'e}e, {I}. and {B}ain, {O}.}, editor = {}, language = {{ENG}}, abstract = {{T}richosomoides nasalis ({T}richinelloidea) is a parasite of {A}rvicanthis niloticus ({M}uridae) in {S}enegal. {F}emale worms that harbour dwarf males in their uteri, occur in the epithelium of the nasal mucosa. {Y}oung laboratory-bred {A}. niloticus were either fed females containing larvated eggs or intraperitoneally injected with motile first-stage larvae recovered from female uteri. {B}oth resulted in successful infection. {O}rgans examined during rodent necropsy were blood and lymphatic circulatory systems (heart, large vessels, lymphnodes), lungs, liver, kidneys, thoracic and abdominal cavities, thoracic and abdominal muscular walls, diaphragm, tongue, and nasal mucosa. {D}evelopment to adult nasal stages took three weeks. {R}ecovery of newly hatched larvae from the peritoneal fluid at four-eight hours after oral infection suggests a direct passage from the stomach or intestinal wall to the musculature. {H}owever, dissemination through the blood, as observed with {T}richinella spiralis, cannot be excluded even though newly hatched larvae of {T} nasalis are twice as thick (15 mu m). {D}eveloping larvae were found in histological sections of the striated muscle of the abdominal and thoracic walls, and larvae in fourth moult were dissected from these sites. {A}dult females were found in the deep nasal mucosa where mating occurred prior to worms settling in the nasal epithelium. {T}he present study shows a remarkable similarity between {T} nasalis and {T}richinella species regarding muscle tropism, but the development of {T}. nasalis is not arrested at the late first-larval stage and does not induce transformation of infected fibres into nurse cells. {T}. nasalis seems a potential model to study molecular relations between trichinelloid larvae and infected muscle fibres.}, keywords = {{T}richosomoides ; {T}richinella ; rodent ; intramuscular development}, booktitle = {}, journal = {{P}arasite : {J}ournal de la {S}oci{\'e}t{\'e} {F}ran{\c{c}}aise de {P}arasitologie}, volume = {19}, numero = {1}, pages = {19--29}, ISSN = {1252-607{X}}, year = {2012}, URL = {https://www.documentation.ird.fr/hor/fdi:010055697}, }