Zampella A. auteur aut IRD Sepe V. auteur aut IRD Luciano P. auteur aut IRD Bellotta F. auteur aut IRD Monti M. C. auteur aut IRD Auria D' M. V. auteur aut IRD Jepsen T. auteur aut IRD Petek S. auteur aut IRD Adeline M. T. auteur aut IRD Laprevote O. auteur aut IRD Aubertin A. M. auteur aut IRD Debitus Cécile auteur aut IRD Poupat C. auteur aut IRD Ahond A. auteur aut IRD text journalArticle eng text/pdf born digital access A new anti-HIV cyclodepsipeptide, homophymine A, was isolated from a New Caledonian collection of the marine sponge Homophymia sp. The structure of homophymine A was determined by interpretation of spectroscopic data, acid hydrolysis, and LC-MS analysis. Homophymine A contains 11 amino acid residues and an amide-linked 3-hydroxy-2,4,6-trimethyloctanoic acid moiety. Along with four D-, two L-, and one N-methyl arnino acids, it also contains four unusual amino acid residues: (2S,3S,4R)-3,4diMe-Gln, (2R,3R,4S)-4-amino-2,3-dihydroxy-1,7-heptandioic acid, L-ThrOMe, and (2R,3R,4R)-2-amino3-hydroxy-4,5-dimethylhexanoic acid. In a cell-based XTT assay, homophymine A exhibited cytoprotective activity against HIV-1 infection with a IC50 of 75 nM. specialized NOUVELLE CALEDONIE 035 73 14 5319-5327 2008 0022-3263 https://www.documentation.ird.fr/hor/fdi:010055302 10.1021/jo800583b 0022-3263 [F B010055302] https://www.documentation.ird.fr/hor/fdi:010055302 https://www.documentation.ird.fr/intranet/publi/depot/2012-05-21/010055302.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2008-09-19 2017-08-23 fdi:010055302 fre