Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp Journal of Organic Chemistry 5319-5327 NOUVELLE CALEDONIE 2008 fdi:010055302 ENG Journal of Organic Chemistry 0022-3263 ISI:000257543100015 14 10.1021/jo800583b https://www.documentation.ird.fr/hor/fdi:010055302 https://www.documentation.ird.fr/intranet/publi/depot/2012-05-21/010055302.pdf 73 Horizon (IRD) A new anti-HIV cyclodepsipeptide, homophymine A, was isolated from a New Caledonian collection of the marine sponge Homophymia sp. The structure of homophymine A was determined by interpretation of spectroscopic data, acid hydrolysis, and LC-MS analysis. Homophymine A contains 11 amino acid residues and an amide-linked 3-hydroxy-2,4,6-trimethyloctanoic acid moiety. Along with four D-, two L-, and one N-methyl arnino acids, it also contains four unusual amino acid residues: (2S,3S,4R)-3,4diMe-Gln, (2R,3R,4S)-4-amino-2,3-dihydroxy-1,7-heptandioic acid, L-ThrOMe, and (2R,3R,4R)-2-amino3-hydroxy-4,5-dimethylhexanoic acid. In a cell-based XTT assay, homophymine A exhibited cytoprotective activity against HIV-1 infection with a IC50 of 75 nM. 035 UR152