%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Zampella, A.
%A Sepe, V.
%A Luciano, P.
%A Bellotta, F.
%A Monti, M. C.
%A Auria D', M. V.
%A Jepsen, T.
%A Petek, S.
%A Adeline, M. T.
%A Laprevote, O.
%A Aubertin, A. M.
%A Debitus, Cécile
%A Poupat, C.
%A Ahond, A.
%T Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp
%D 2008
%L fdi:010055302
%G ENG
%J Journal of Organic Chemistry
%@ 0022-3263
%K NOUVELLE CALEDONIE
%M ISI:000257543100015
%N 14
%P 5319-5327
%R 10.1021/jo800583b
%U https://www.documentation.ird.fr/hor/fdi:010055302
%> https://www.documentation.ird.fr/intranet/publi/depot/2012-05-21/010055302.pdf
%V 73
%W Horizon (IRD)
%X A new anti-HIV cyclodepsipeptide, homophymine A, was isolated from a New Caledonian collection of the marine sponge Homophymia sp. The structure of homophymine A was determined by interpretation of spectroscopic data, acid hydrolysis, and LC-MS analysis. Homophymine A contains 11 amino acid residues and an amide-linked 3-hydroxy-2,4,6-trimethyloctanoic acid moiety. Along with four D-, two L-, and one N-methyl arnino acids, it also contains four unusual amino acid residues: (2S,3S,4R)-3,4diMe-Gln, (2R,3R,4S)-4-amino-2,3-dihydroxy-1,7-heptandioic acid, L-ThrOMe, and (2R,3R,4R)-2-amino3-hydroxy-4,5-dimethylhexanoic acid. In a cell-based XTT assay, homophymine A exhibited cytoprotective activity against HIV-1 infection with a IC50 of 75 nM.
%$ 035