Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp Zampella, A. Sepe, V. Luciano, P. Bellotta, F. Monti, M. C. Auria D', M. V. Jepsen, T. Petek, S. Adeline, M. T. Laprevote, O. Aubertin, A. M. /Debitus, Cécile Poupat, C. Ahond, A. A new anti-HIV cyclodepsipeptide, homophymine A, was isolated from a New Caledonian collection of the marine sponge Homophymia sp. The structure of homophymine A was determined by interpretation of spectroscopic data, acid hydrolysis, and LC-MS analysis. Homophymine A contains 11 amino acid residues and an amide-linked 3-hydroxy-2,4,6-trimethyloctanoic acid moiety. Along with four D-, two L-, and one N-methyl arnino acids, it also contains four unusual amino acid residues: (2S,3S,4R)-3,4diMe-Gln, (2R,3R,4S)-4-amino-2,3-dihydroxy-1,7-heptandioic acid, L-ThrOMe, and (2R,3R,4R)-2-amino3-hydroxy-4,5-dimethylhexanoic acid. In a cell-based XTT assay, homophymine A exhibited cytoprotective activity against HIV-1 infection with a IC50 of 75 nM. 2008 text https://www.documentation.ird.fr/hor/fdi:010055302 fdi:010055302 Zampella A., Sepe V., Luciano P., Bellotta F., Monti M. C., Auria D' M. V., Jepsen T., Petek S., Adeline M. T., Laprevote O., Aubertin A. M., Debitus Cécile, Poupat C., Ahond A.. Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp. 2008, 73 (14), 5319-5327 EN NOUVELLE CALEDONIE