@article{fdi:010055302,
  title = {{H}omophymine {A}, an anti-{HIV} cyclodepsipeptide from the sponge {H}omophymia sp},
  author = {{Z}ampella, {A}. and {S}epe, {V}. and {L}uciano, {P}. and {B}ellotta, {F}. and {M}onti, {M}. {C}. and {A}uria {D}', {M}. {V}. and {J}epsen, {T}. and {P}etek, {S}. and {A}deline, {M}. {T}. and {L}aprevote, {O}. and {A}ubertin, {A}. {M}. and {D}ebitus, {C}{\'e}cile and {P}oupat, {C}. and {A}hond, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A} new anti-{HIV} cyclodepsipeptide, homophymine {A}, was isolated from a {N}ew {C}aledonian collection of the marine sponge {H}omophymia sp. {T}he structure of homophymine {A} was determined by interpretation of spectroscopic data, acid hydrolysis, and {LC}-{MS} analysis. {H}omophymine {A} contains 11 amino acid residues and an amide-linked 3-hydroxy-2,4,6-trimethyloctanoic acid moiety. {A}long with four {D}-, two {L}-, and one {N}-methyl arnino acids, it also contains four unusual amino acid residues: (2{S},3{S},4{R})-3,4di{M}e-{G}ln, (2{R},3{R},4{S})-4-amino-2,3-dihydroxy-1,7-heptandioic acid, {L}-{T}hr{OM}e, and (2{R},3{R},4{R})-2-amino3-hydroxy-4,5-dimethylhexanoic acid. {I}n a cell-based {XTT} assay, homophymine {A} exhibited cytoprotective activity against {HIV}-1 infection with a {IC}50 of 75 n{M}.},
  keywords = {{NOUVELLE} {CALEDONIE}},
  booktitle = {},
  journal = {{J}ournal of {O}rganic {C}hemistry},
  volume = {73},
  numero = {14},
  pages = {5319--5327},
  ISSN = {0022-3263},
  year = {2008},
  DOI = {10.1021/jo800583b},
  URL = {https://www.documentation.ird.fr/hor/fdi:010055302},
}