%0 Unpublished Work
%9 AP : Autres productions
%A Chippaux, Jean-Philippe
%A Santalla, J.
%A Salas Clavijo, Alexandra
%A Schneider, Dominique
%A Postigo, Jorge
%A Romero, Mario
%A Rios, T.
%A Oreste Arnez Aponte, L.
%A Cabrera Mendez, J.C.
%A Roman, E.
%T Informe final : optimizacion y validacion del tratamiento de la enfermedad de Chagas congénita (noviembre 2006-Diciembre 2008)
%B Proyecto de lucha contra las grandes endemias : informe technico final
%C La Paz (BOL) ; La Paz
%D 2009
%L fdi:010055127
%G SPA
%I INLASA ; IRD
%K MALADIE DE CHAGAS ; LUTTE ; GROSSESSE ; TRAITEMENT MEDICAL ; DOSE ; EFFICACITE ; SEROLOGIE ; COMMUNAUTE AMERINDIENNE ; ESSAI CLINIQUE ; ETUDE COMPARATIVE ; PROJET DE RECHERCHE
%K BENZNIDAZOL ; TRANSMISSION MERE ENFANT ; EFFET SECONDAIRE ; TEST ELISA
%K BOLIVIE ; LA PAZ ; ANDES
%P 104-142
%U https://www.documentation.ird.fr/hor/fdi:010055127
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers19-04/010055127.pdf
%W Horizon (IRD)
%X Objective: Data on the epidemiology of the Teniasis/Cysticercosis complex in the Department of a Paz, Bolivia, are very scarce, even if #Taenia solium$ is known to be endemic in the area. Thus, in the present study, we tried to identify the way of contamination of the human by the larvae of #Taenia solium$, and to evaluate the prevalence of teniasis in several communities located in the Altiplano. Methods: A cross-sectional survey has been concluted in three rural communities located in the privince of Los Andes. the prevalence of taeniasis has been measured through coprological examinations including a direct microscopic examination and examination using Ritchie's concentration methods. A questionnaire has been aplied to collect information on the socio-economic environment, the displacements and the nutritional habits of each person. Another questionnaire, elaborated by the IENT, will be applied to identify people who suffer of epilepsy and to characterize the clinical presentation of the latter. The a CT-scan examination and a serodetection of antigens of #T. solium$ will be performed on people with epilepsy in order to identify those patients with neurocysticercosis. The study of the contaminant potential in order to identify those patients with neurocysticercosis. The study of the contaminant potential of food was realized in a rural community, as well as in the cities of La Paz and El Alto. Samples of cooked ig meat had been bought, dissected (thickness 0.5 cm wide) and the viability of the cysticerci present in the pieces of meat has been analyzed. The infective potential of the parasite was assessed by the capacity of evagination of the cysticerci preciously washed with a saline solution and left to incubate in a Petri box containing a saline solution at 20% of fresh bovine bile diluted in physiological serum. Results: A total of 269 faecal samples has been collected among the three communities visited. No egg of #Taenia$ sp. was found neither by direct examination of stools nor by te Ritchie's concentration techniques. Three cases of infection by helminth parasites have been recorded: two cases with #Hymenolepis nana$ (1,!%) and one with #Enterobius vermicularis$ (0,4%). In addition, the patients showed high rates of infection by protozoan parasites: #Entamoeba coli$ (59,8%), #Endolimx nana$ (49,8%), #Blastocystis hominis$ (47,6%), #Chilomastix mesnili$ (14,1%), #Giardia lamblia$ (10,8%), #Entamoeba histolytica$ (10,8%) and #Iodamoeba butschlii$ (9,7%). A rigorous disection of the 120 food samples was made. 75 samples were bought in La Paz, 38 in El Alto and 7 in the village of Batallas on the Altiplano. Cysticerci were found in only one of the 75 samples which represents 0,8% of all the samples. The 10 cysticerci found were incubated during 24h in bovine bile diluted in physiological serum for testing their viability. None of them started to evaginate, thus they were al non-viable. Conclusion: According to our results, the prevalence of teniasis is very low in this part of the Bolivian Altiplano. A decrease of the prevalence of taeniasis probably occurred durging this last years, thanks to the National Programme for the Prevention and Control of Teniasis-Cysticercosis started in 1994. The apparent low rate of porcine infection by cysticercosis in this region may be due to changes in the husbandry practices or to an improvement in hygiene habits (90% of the population have latrines). No contaminating food was found during the study. the contamination of the human by infectious food may occur at Chrstmas when the marketing of pork meat increases dramatically in the city. (résumé d'auteur)
%$ 052GLOTRY03