Mancini I. auteur aut IRD Guella G. auteur aut IRD Frostin M. auteur aut IRD Hnawia E. auteur aut IRD Laurent Dominique auteur aut IRD Debitus Cécile auteur aut IRD Pietra F. auteur aut IRD text journalArticle eng text/pdf born digital access Reported here is the first polyarsenic compound ever found in nature. Denominated arsenicin A, it was isolated along a bioassay-guided fractionation of the organic extract of the poecilosclerid sponge Echinochalina bargibanti collected from the northeastern coast of New Caledonia. In defining an adamantine-type polyarsenic structure for this compound, deceptively simple NMR spectra were complemented by extensive mass spectral analysis. However, it was only the synthesis of a model compound that provided the basis to discriminate structure 4 from other spectrally compatible structures for arsenicin A; to this end, a comparative ab initio simulation of IR spectra for the natural and the synthetic compounds was decisive. Arsenicin A is endowed with potent bactericidal and fungicidal activities on human pathogenic strains. All this may revive pharmacological interest in arsenic compounds while prompting us to rethink the arsenic cycle in nature. specialized ab initio calculations antibiotics arsenic mass spectrometry natural products 035 12 35 8989-8994 2006 0947-6539 https://www.documentation.ird.fr/hor/fdi:010055024 10.1002/chem.200600783 0947-6539 [F B010055024] https://www.documentation.ird.fr/hor/fdi:010055024 https://www.documentation.ird.fr/intranet/publi/depot/2012-04-05/010055024.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2007-01-29 2017-08-23 fdi:010055024 fre