%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Mancini, I.
%A Guella, G.
%A Frostin, M.
%A Hnawia, E.
%A Laurent, Dominique
%A Debitus, Cécile
%A Pietra, F.
%T On the first polyarsenic organic compound from nature : Arsenicin A from the New Caledonian marine sponge Echinochalina bargibanti
%D 2006
%L fdi:010055024
%G ENG
%J Chemistry a European Journal
%@ 0947-6539
%K ab initio calculations ; antibiotics ; arsenic ; mass spectrometry ; natural products
%M CC:0002427935-0009
%N 35
%P 8989-8994
%R 10.1002/chem.200600783
%U https://www.documentation.ird.fr/hor/fdi:010055024
%> https://www.documentation.ird.fr/intranet/publi/depot/2012-04-05/010055024.pdf
%V 12
%W Horizon (IRD)
%X Reported here is the first polyarsenic compound ever found in nature. Denominated arsenicin A, it was isolated along a bioassay-guided fractionation of the organic extract of the poecilosclerid sponge Echinochalina bargibanti collected from the northeastern coast of New Caledonia. In defining an adamantine-type polyarsenic structure for this compound, deceptively simple NMR spectra were complemented by extensive mass spectral analysis. However, it was only the synthesis of a model compound that provided the basis to discriminate structure 4 from other spectrally compatible structures for arsenicin A; to this end, a comparative ab initio simulation of IR spectra for the natural and the synthetic compounds was decisive. Arsenicin A is endowed with potent bactericidal and fungicidal activities on human pathogenic strains. All this may revive pharmacological interest in arsenic compounds while prompting us to rethink the arsenic cycle in nature.
%$ 035