@article{fdi:010055024,
  title = {{O}n the first polyarsenic organic compound from nature : {A}rsenicin {A} from the {N}ew {C}aledonian marine sponge {E}chinochalina bargibanti},
  author = {{M}ancini, {I}. and {G}uella, {G}. and {F}rostin, {M}. and {H}nawia, {E}. and {L}aurent, {D}ominique and {D}ebitus, {C}{\'e}cile and {P}ietra, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{R}eported here is the first polyarsenic compound ever found in nature. {D}enominated arsenicin {A}, it was isolated along a bioassay-guided fractionation of the organic extract of the poecilosclerid sponge {E}chinochalina bargibanti collected from the northeastern coast of {N}ew {C}aledonia. {I}n defining an adamantine-type polyarsenic structure for this compound, deceptively simple {NMR} spectra were complemented by extensive mass spectral analysis. {H}owever, it was only the synthesis of a model compound that provided the basis to discriminate structure 4 from other spectrally compatible structures for arsenicin {A}; to this end, a comparative ab initio simulation of {IR} spectra for the natural and the synthetic compounds was decisive. {A}rsenicin {A} is endowed with potent bactericidal and fungicidal activities on human pathogenic strains. {A}ll this may revive pharmacological interest in arsenic compounds while prompting us to rethink the arsenic cycle in nature.},
  keywords = {ab initio calculations ; antibiotics ; arsenic ; mass spectrometry ; natural products},
  booktitle = {},
  journal = {{C}hemistry a {E}uropean {J}ournal},
  volume = {12},
  numero = {35},
  pages = {8989--8994},
  ISSN = {0947-6539},
  year = {2006},
  DOI = {10.1002/chem.200600783},
  URL = {https://www.documentation.ird.fr/hor/fdi:010055024},
}