@article{fdi:010054733,
  title = {{P}arasitic co-infections : does {A}scaris lumbricoides protect against {P}lasmodium falciparum infection ?},
  author = {{B}rutus, {L}aurent and {W}atier, {L}. and {B}riand, {V}al{\'e}rie and {H}anitrasoamampionona, {V}. and {R}azanatsoarilala, {H}. and {C}ot, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{A} controlled randomized trial of antihelminthic treatment was undertaken in 1996-1997 in a rural area of {M}adagascar where populations were simultaneously infected with {A}scaris lumbricoides and {P}lasmodium falciparum. {L}evamisole was administered bimonthly to 164 subjects, randomized on a family basis, whereas 186 were controls. {W}hile levamisole proved to be highly effective in reducing {A}scaris egg loads in the treated group ({P} < 10(-3) at all bimonthly visits), subjects more than 5 years of age, treated with levamisole had a significant increase in their {P}. falciparum densities compared with controls ({P} = 0.02), whereas there was no effect of anti-helminthic treatment on children 6 months to 4 years of age. {T}he demonstration of a clear negative interaction between {A}scaris infection and malaria parasite density has important implications. {S}ingle community therapy programs to deliver treatments against several parasitic infections could avoid an increase of malaria attacks after mass treatment of ascariasis.},
  keywords = {{MADAGASCAR}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {75},
  numero = {2},
  pages = {194--198},
  ISSN = {0002-9637},
  year = {2006},
  URL = {https://www.documentation.ird.fr/hor/fdi:010054733},
}