@article{fdi:010054720,
  title = {{T}ransmission of simian immunodeficiency virus {SIV}cpz and the evolution of infection in the presence and absence of concurrent human immunodeficiency virus type 1 infection in chimpanzees},
  author = {{H}eeney, {J}.{L}. and {R}utjens, {E}. and {V}erschoor, {E}.{J}. and {N}iphuis, {H}. and {T}en {H}aaft, {P}. and {R}ouse, {S}. and {M}c{C}lure, {H}. and {B}alla {J}hagjhoorsingh, {S}. and {B}ogers, {W}. and {S}alas, {M}. and {C}obb, {K}. and {K}estens, {L}. and {D}avis, {D}. and {V}an der {G}roen, {G}. and {C}ourgnaud, {V}al{\'e}rie and {P}eeters, {M}artine and {M}urthy, {K}.{K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}urrent data suggest that the human immunodeficiency virus type 1 ({HIV}-1) epidemic arose by transmission of simian immunodeficiency virus ({SIV}) {SIV}cpz from a subspecies of common chimpanzees ({P}an troglodytes troglodytes) to humans. {SIV}cpz of chimpanzees is itself a molecular chimera of {SIV}s from two or more different monkey species, suggesting that recombination was made possible by coinfection of one individual animal with different lentiviruses. {H}owever, very little is known about {SIV}cpz transmission and the susceptibility to lentivirus coinfection of its natural host, the chimpanzee. {H}ere, it is revealed that either infected plasma or peripheral blood mononuclear cells readily confer infection when exposure occurs by the intravenous or mucosal route. {I}mportantly, the presence of preexisting {HIV}-1 infection did not modify the kinetics of {SIV}cpz infection once it was established by different routes. {A}lthough humoral responses appeared as early as 4 weeks postinfection, neutralization to {SIV}cpz-{ANT} varied markedly between animals. {A}nalysis of the {SIV}cpz env sequence over time revealed the emergence of genetic viral variants and persistent {SIV}cpz {RNA} levels of between 10(4) and 10(5) copies/ml plasma regardless of the presence or absence of concurrent {HIV}-1 infection. {T}hese unique data provide important insight into possible routes of transmission, the kinetics of acute {SIV}cpz infection, and how readily coinfection with {SIV}cpz and other lentiviruses may be established as necessary preconditions for potential recombination.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {V}irology},
  volume = {80},
  numero = {14},
  pages = {7208--7218},
  ISSN = {0022-538{X}},
  year = {2006},
  DOI = {10.1128/{JVI}.00382-06},
  URL = {https://www.documentation.ird.fr/hor/fdi:010054720},
}