@article{fdi:010054394, title = {{M}olecular evolution of the insect-specific flaviviruses}, author = {{C}ook, {S}. and {M}oureau, {G}r{\'e}gory and {K}itchen, {A}. and {G}ould, {E}. {A}. and de {L}amballerie, {X}avier and {H}olmes, {E}. {C}. and {H}arbachl, {R}. {E}.}, editor = {}, language = {{ENG}}, abstract = {{T}here has been an explosion in the discovery of 'insect-specific' flaviviruses and/or their related sequences in natural mosquito populations. {H}erein we review all 'insect-specific' flavivirus sequences currently available and conduct phylogenetic analyses of both the 'insect-specific' flaviviruses and available sequences of the entire genus {F}lavivirus. {W}e show that there is no statistical support for virus mosquito co-divergence, suggesting that the 'insect-specific' flaviviruses may have undergone multiple introductions with frequent host switching. {W}e discuss potential implications for the evolution of vectoring within the family {F}laviviridae. {W}e also provide preliminary evidence for potential recombination events in the history of cell fusing agent virus. {F}inally, we consider priorities and guidelines for future research on 'insect-specific' flaviviruses, including the vast potential that exists for the study of biodiversity within a range of potential hosts and vectors, and its effect on the emergence and maintenance of the flaviviruses.}, keywords = {}, booktitle = {}, journal = {{J}ournal of {G}eneral {V}irology}, volume = {93}, numero = {{P}art 2}, pages = {223--234}, ISSN = {0022-1317}, year = {2012}, DOI = {10.1099/vir.0.036525-0}, URL = {https://www.documentation.ird.fr/hor/fdi:010054394}, }