@article{fdi:010054360,
  title = {{T}ropheryma whipplei : a common bacterium in rural {S}enegal},
  author = {{K}eita, {A}.{K}. and {B}assene, {H}. and {T}all, {A}. and {S}okhna, {C}heikh and {R}atmanov, {P}. and {T}rape, {J}ean-{F}ran{\c{c}}ois and {R}aoult, {D}idier and {F}enollar, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}ropheryma whipplei is known as the cause of {W}hipple's disease, but it is also an emerging pathogen, detected in stool, that causes various chronic localized infections without histological digestive involvement and is associated with acute infections, including gastroenteritis and bacteremia. {M}ethods/{P}rincipal {F}indings: {W}e conducted a study in 2008 and 2009 using 497 non-diarrheic and diarrheic stool samples, 370 saliva samples, 454 sera samples and 105 samples obtained from water samples in two rural {S}ine-{S}aloum villages ({D}ielmo and {N}diop) in {S}enegal. {T}he presence of {T}. whipplei was investigated by using specific quantitative {PCR}. {G}enotyping was performed on positive samples. {A} serological analysis by western blotting was performed to determine the seroprevalence and to detect seroconversion. {O}verall, {T}. whipplei was identified in 31.2% of the stool samples (139/446) and 3.5% of the saliva samples (13/370) obtained from healthy subjects. {T}he carriage in the stool specimens was significantly (p<10(-3)) higher in children who were between 0 and 4 years old (60/80, 75%) compared to samples obtained from individuals who were between 5 to 10 years old (36/119, 30.2%) or between 11 and 99 years old (43/247, 17.4%). {T}he carriage in the stool was also significantly more common (p = 0.015) in subjects with diarrhea (25/51, 49%). {W}e identified 22 genotypes, 16 of which were new. {O}nly one genotype (#53) was common to both villages. {A}mong the specific genotypes, one ($52) was epidemic in {D}ielmo (15/28, 53.4%, p<10(-3)) and another (#49) in {N}diop (27.6%, p = 0.002). {T}he overall seroprevalence was estimated at 72.8% (291/400). {S}eroconversion was detected in 66.7% (18/27) of children for whom {PCR} became positive in stools between 2008 and 2009. {C}onclusions/{S}ignificance: {T}. whipplei is a common bacterium in the {S}ine-{S}aloum area of rural {S}enegal that is contracted early in childhood. {E}pidemic genotypes suggest a human transmission of the bacterium.},
  keywords = {{SENEGAL}},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {5},
  numero = {12},
  pages = {e1403},
  ISSN = {1935-2727},
  year = {2011},
  DOI = {10.1371/journal.pntd.0001403},
  URL = {https://www.documentation.ird.fr/hor/fdi:010054360},
}