@article{fdi:010054356,
  title = {{M}ultifaceted population structure and reproductive strategy in {L}eishmania donovani complex in one sudanese village},
  author = {{R}ougeron, {V}irginie and {D}e {M}eeûs, {T}hierry and {H}ide, {M}. and {L}e {F}alher, {G}. and {B}ucheton, {B}runo and {D}ereure, {J}. and {E}l-{S}afi, {S}.{H}. and {D}essein, {A}. and {B}anuls, {A}nne-{L}aure},
  editor = {},
  language = {{ENG}},
  abstract = {{L}eishmania species of the subgenus {L}eishmania and especially {L}. donovani are responsible for a large proportion of visceral leishmaniasis cases. {T}he debate on the mode of reproduction and population structure of {L}eishmania parasites remains opened. {I}t has been suggested that {L}eishmania parasites could alternate different modes of reproduction, more particularly clonality and frequent recombinations either between related individuals (endogamy) or between unrelated individuals (outcrossing) within strongly isolated subpopulations. {T}o determine whether this assumption is generalized to other species, a population genetics analysis within {L}eishmania donovani complex strains was conducted within a single village. {T}he results suggest that a mixed-mating reproduction system exists, an important heterogeneity of subsamples and the coexistence of several genetic entities in {S}udanese {L}. donovani. {I}ndeed, results showed significant genetic differentiation between the three taxa ({L}. donovani, {L}. infantum and {L}. archibaldi) and between the human or canine strains of such taxa, suggesting that there may be different imbricated transmission cycles involving either dogs or humans. {R}esults also are in agreement with an almost strict specificity of {L}. donovani stricto sensu to human hosts. {T}his empirical study demonstrates the complexity of population structure in the genus {L}eishmania and the need to pursue such kind of analyses at the smallest possible spatio-temporal and ecological scales.},
  keywords = {{SOUDAN}},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {5},
  numero = {12},
  pages = {e1448},
  ISSN = {1935-2727},
  year = {2011},
  DOI = {10.1371/journal.pntd.0001448},
  URL = {https://www.documentation.ird.fr/hor/fdi:010054356},
}