@article{fdi:010054300,
  title = {{R}elationship between exposure to vector bites and antibody responses to mosquito salivary gland extracts},
  author = {{F}ontaine, {A}. and {P}ascual, {A}. and {O}rlandi-{P}radines, {E}. and {D}iouf, {I}. and {R}emou{\'e}, {F}ranck and {P}ages, {F}. and {F}usai, {T}. and {R}ogier, {C}. and {A}lmeras, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}osquito-borne diseases are major health problems worldwide. {S}erological responses to mosquito saliva proteins may be useful in estimating individual exposure to bites from mosquitoes transmitting these diseases. {H}owever, the relationships between the levels of these {I}g{G} responses and mosquito density as well as {I}g{G} response specificity at the genus and/or species level need to be clarified prior to develop new immunological markers to assess human/vector contact. {T}o this end, a kinetic study of antibody levels against several mosquito salivary gland extracts from southeastern {F}rench individuals living in three areas with distinct ecological environments and, by implication, distinct {A}edes caspius mosquito densities were compared using {ELISA}. {A} positive association was observed between the average levels of {I}g{G} responses against {A}e. caspius salivary gland extracts and spatial {A}e. caspius densities. {A}dditionally, the average level of {I}g{G} responses increased significantly during the peak exposure to {A}e. caspius at each site and returned to baseline four months later, suggesting short-lived {I}g{G} responses. {T}he species-specificity of {I}g{G} antibody responses was determined by testing antibody responses to salivary gland extracts from {C}x. pipiens, a mosquito that is present at these three sites at different density levels, and from two other {A}edes species not present in the study area ({A}e. aegypti and {A}e. albopictus). {T}he {I}g{G} responses observed against these mosquito salivary gland extracts contrasted with those observed against {A}e. caspius salivary gland extracts, supporting the existence of species-specific serological responses. {B}y considering different populations and densities of mosquitoes linked to environmental factors, this study shows, for the first time, that specific {I}g{G} antibody responses against {A}e. caspius salivary gland extracts may be related to the seasonal and geographical variations in {A}e. caspius density. {C}haracterisation of such immunological-markers may allow the evaluation of the effectiveness of vector-control strategies or estimation of the risk of vector-borne disease transmission.},
  keywords = {{FRANCE}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {6},
  numero = {12},
  pages = {e29107},
  ISSN = {1932-6203},
  year = {2011},
  DOI = {10.1371/journal.pone.0029107},
  URL = {https://www.documentation.ird.fr/hor/fdi:010054300},
}