@article{fdi:010054289,
  title = {{B}iodegradable polymeric nanoformulation based on the antiprotozoal canthin-6-one},
  author = {{A}rias, {J}. {L}. and {C}ebrian-{T}orrejon, {G}. and {P}oupon, {E}. and {F}ournet, {A}lain and {C}ouvreur, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he efficacy of antiprotozoal agents against intracellular infections is very often limited by an almost negligible access to the cellular level where the pathogens are hidden. {A}s a result, high doses of the chemotherapy agents are needed to be administered, but the great incidence of severe adverse drug effects generally leads to pharmacotherapy failure. {T}o enhance the pharmacological effect of the antiprotozoal and antifungal canthin-6-one, loading into biodegradable poly(octylcyanoacrylate) nanoparticles has been considered. {T}he preparation of canthin-6-one nanoformulation (average size a parts per thousand 170 nm) has been performed by a single-absorption procedure with high drug loading and little burst release as determined by {RP}-{HPLC}. {F}urther characterization of this nanoformulation has been carry out by electrophoretic measurements, analysis of the surface thermodynamics of the nanoparticles, and (1){H}-{NMR} analysis. {N}anoparticles loaded with canthin-6-one were characterized by a significant hydrophobicity and a great surface electrical charge under physiological conditions. {T}hese are two key physicochemical factors determining recognition by the reticuloendothelial system, resulting in a fast intracellular uptake by infected phagocytes. {I}t is expected that this nanoformulation offers potential applications for an efficient canthin-6-one delivery to intracellular infections.},
  keywords = {{C}anthin-6-one ; {D}rug delivery ; {I}ntracellular infection ; {N}anoformulation ; {P}oly(octylcyanoacrylate) ; {R}eticuloendothelial system},
  booktitle = {},
  journal = {{J}ournal of {N}anoparticle {R}esearch},
  volume = {13},
  numero = {12},
  pages = {6737--6746},
  ISSN = {1388-0764},
  year = {2011},
  DOI = {10.1007/s11051-011-0580-z},
  URL = {https://www.documentation.ird.fr/hor/fdi:010054289},
}